D1 and D2 medium spiny neurons in the nucleus accumbens core have distinct and valence-independent roles in learning
At the core of value-based learning is the nucleus accumbens (NAc). D1-and D2-receptor-
containing medium spiny neurons (MSNs) in the NAc core are hypothesized to have …
containing medium spiny neurons (MSNs) in the NAc core are hypothesized to have …
Neuropeptide Y modulates excitatory synaptic transmission and promotes social behavior in the mouse nucleus accumbens
Social interactions define the human experience, but these integral behaviors are disrupted
in many psychiatric disorders. Social behaviors have evolved over millennia, and …
in many psychiatric disorders. Social behaviors have evolved over millennia, and …
Kappa opioid receptor modulation of excitatory drive onto nucleus accumbens fast-spiking interneurons
BC Coleman, KM Manz, BA Grueter - Neuropsychopharmacology, 2021 - nature.com
The dynorphin/kappa opioid receptor (KOR) system within the nucleus accumbens (NAc)
contributes to affective states. Parvalbumin fast-spiking interneurons (PV-FSIs), a key …
contributes to affective states. Parvalbumin fast-spiking interneurons (PV-FSIs), a key …
An ensemble recruited by α2a-adrenergic receptors is engaged in a stressor-specific manner in mice
JA Brown, N Petersen, SW Centanni, AY Jin… - …, 2023 - nature.com
Abstract α2a-adrenergic receptor (α2a-AR) agonists are candidate substance use disorder
therapeutics due to their ability to recruit noradrenergic autoreceptors to dampen stress …
therapeutics due to their ability to recruit noradrenergic autoreceptors to dampen stress …
[HTML][HTML] A cocaine-activated ensemble exerts increased control over behavior while decreasing in size
Background Substance use disorder (SUD) is characterized by long-lasting changes in
reward-related brain regions, such as the nucleus accumbens (NAc). Previous work has …
reward-related brain regions, such as the nucleus accumbens (NAc). Previous work has …
Cannabinoid type 1 receptors in A2a neurons contribute to cocaine-environment association
Rationale Cannabinoid type 1 receptors (CB1Rs) are widely expressed within the brain's
reward circuits and are implicated in regulating drug induced behavioral adaptations …
reward circuits and are implicated in regulating drug induced behavioral adaptations …
Kappa opioid receptor modulation of nucleus accumbens feedforward inhibitory microcircuits
BC Coleman - 2022 - search.proquest.com
The dynorphin/kappa opioid receptor (KOR) system within the nucleus accumbens (NAc)
contributes to negative affective states following withdrawal from illicit drugs, pain, and …
contributes to negative affective states following withdrawal from illicit drugs, pain, and …
Microcircuit Mechanisms Regulating Nucleus Accumbens Circuit Function
KM Manz - 2019 - ir.vanderbilt.edu
The nucleus accumbens (NAc) is implicated in the pathogenesis of conditions characterized
by maladaptive motivational states, including addiction and depression. Embedded within …
by maladaptive motivational states, including addiction and depression. Embedded within …