Endocannabinoid signaling at the periphery: 50 years after THC
In 1964, the psychoactive ingredient of Cannabis sativa, Δ 9-tetrahydrocannabinol (THC),
was isolated. Nearly 30 years later the endogenous counterparts of THC, collectively termed …
was isolated. Nearly 30 years later the endogenous counterparts of THC, collectively termed …
The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: Δ9tetrahydrocannabinol, cannabidiol and Δ9tetrahydrocannabivarin
RG Pertwee - British journal of pharmacology, 2008 - Wiley Online Library
Cannabis sativa is the source of a unique set of compounds known collectively as plant
cannabinoids or phytocannabinoids. This review focuses on the manner with which three of …
cannabinoids or phytocannabinoids. This review focuses on the manner with which three of …
Pharmacokinetics and pharmacodynamics of cannabinoids
F Grotenhermen - Clinical pharmacokinetics, 2003 - Springer
Abstract Δ 9-Tetrahydrocannabinol (THC) is the main source of the pharmacological effects
caused by the consumption of cannabis, both the marijuana-like action and the medicinal …
caused by the consumption of cannabis, both the marijuana-like action and the medicinal …
The endocannabinoid system as an emerging target of pharmacotherapy
The recent identification of cannabinoid receptors and their endogenous lipid ligands has
triggered an exponential growth of studies exploring the endocannabinoid system and its …
triggered an exponential growth of studies exploring the endocannabinoid system and its …
Cannabinoids as novel anti-inflammatory drugs
P Nagarkatti, R Pandey, SA Rieder… - Future medicinal …, 2009 - Taylor & Francis
Cannabinoids are a group of compounds that mediate their effects through cannabinoid
receptors. The discovery of Δ9-tetrahydrocannabinol (THC) as the major psychoactive …
receptors. The discovery of Δ9-tetrahydrocannabinol (THC) as the major psychoactive …
Cannabidiol and other non-psychoactive cannabinoids for prevention and treatment of gastrointestinal disorders: useful nutraceuticals?
Cannabis sativa is an aromatic annual flowering plant with several botanical varieties, used
for different purposes, like the production of fibers, the production of oil from the seeds, and …
for different purposes, like the production of fibers, the production of oil from the seeds, and …
The endocannabinoid system and its therapeutic exploitation
The term'endocannabinoid'—originally coined in the mid-1990s after the discovery of
membrane receptors for the psychoactive principle in Cannabis, Δ9-tetrahydrocannabinol …
membrane receptors for the psychoactive principle in Cannabis, Δ9-tetrahydrocannabinol …
Cannabinoid-based drugs as anti-inflammatory therapeutics
TW Klein - Nature Reviews Immunology, 2005 - nature.com
In the nineteenth century, marijuana was prescribed by physicians for maladies ranging from
eating disorders to rabies. However, as newer, more effective drugs were discovered and as …
eating disorders to rabies. However, as newer, more effective drugs were discovered and as …
Cannabinoids and the gut: new developments and emerging concepts
AA Izzo, KA Sharkey - Pharmacology & therapeutics, 2010 - Elsevier
Cannabis has been used to treat gastrointestinal (GI) conditions that range from enteric
infections and inflammatory conditions to disorders of motility, emesis and abdominal pain …
infections and inflammatory conditions to disorders of motility, emesis and abdominal pain …
Emerging strategies for exploiting cannabinoid receptor agonists as medicines
RG Pertwee - British journal of pharmacology, 2009 - Wiley Online Library
Mandarin translation of abstract Medicines that activate cannabinoid CB1 and CB2 receptor
are already in the clinic. These are Cesamet®(nabilone), Marinol®(dronabinol; Δ9 …
are already in the clinic. These are Cesamet®(nabilone), Marinol®(dronabinol; Δ9 …