Drug dosing in obese patients continues to be challenging due to a lack of high‐quality
evidence to guide dosing recommendations. We first published guidance for antibiotic …

Welcome to the 29th edition of Nelson's Pediatric Antimicrobial Therapy, the third edition
written during the COVID-19 pandemic, which continues to significantly affect our lives and …

Introduction Currently, antibiotic treatment is often a standard dosing regimen in bone and
joint infections (BJI). However, it remains unknown if exposure at the target-site is adequate …

Since 1955, the recommended strategy for rheumatic heart disease (RHD) secondary
prophylaxis has been benzathine penicillin G [BPG; 1.2 MU (900 mg)] injections …

Completely updated and revised, the 29th edition of this best-selling reference provides
instant access to the latest recommendations for treatment of infectious diseases in children …

This chapter reviews the pharmacokinetics (PK) and pharmacodynamics (PD) of antibiotics
in bone and presents methods that support optimized evidence‐based selection of antibiotic …

Subcutaneous (SC) administration of ertapenem in outpatient parenteral antimicrobial
therapy (OPAT) services may be a practical alternative to intravenous delivery for …

Post-licensing pharmacometric studies can provide a better understanding of the
pharmacokinetic (PK) alterations in special patient populations and may lead to better …

As a heterogeneous and wide inflammation, osteoarticular infection (OAI) shows an
increasing incidence in recent years. Staphylococcus aureus is the most important pathogen …

Mendelian randomization (MR) analysis was used to determine the causal relationship
between Type 2 diabetes (T2D) and osteomyelitis (OM). We performed MR analysis using …