Discovery of drug targets and therapeutic agents based on drug repositioning to treat lung adenocarcinoma

OK Graves, W Kim, M Özcan, S Ashraf, H Turkez… - Biomedicine & …, 2023 - Elsevier
Background Lung adenocarcinoma (LUAD) is the one of the most common subtypes in lung
cancer. Although various targeted therapies have been used in the clinical practice, the 5 …

Immune infiltration landscape on prognosis and therapeutic response and relevant epigenetic and transcriptomic mechanisms in lung adenocarcinoma

L Zhang, B Jiang, Z Lan, C Yang, Y Yao, J Lin… - Frontiers in …, 2022 - frontiersin.org
Objective Lung adenocarcinoma (LUAD) is the most prevalent lung cancer subtype, but its
immune infiltration features are not comprehensively understood. To address the issue, the …

KEAP1 and TP53 (Co) mutation in lung adenocarcinoma: another bullet for immunotherapy?

G Pelosi - Journal of Thoracic Oncology, 2021 - jto.org
That impairment of immune response may actually play an active role in the development of
NSCLC, it is well anticipated by the beneficial effects of tumor lymphocytic infiltration on the …

Apatinib plus chemotherapy is associated with an improved tumor response, survival and tolerance compared with chemotherapy alone for advanced lung …

H Ye, W Yu, Y Ni, X Bao, X Zhang, Y Li… - Oncology …, 2024 - spandidos-publications.com
Apatinib plus chemotherapy demonstrates good efficacy in multiple advanced carcinomas;
however, its use in patients with advanced lung adenocarcinoma (LUAD) has not yet been …

The circadian clock circuitry deconvolutes colorectal cancer and lung adenocarcinoma heterogeneity in a dynamic time-related framework

V Melocchi, R Cuttano, E Murgo, G Mazzoccoli… - Cancer Gene …, 2023 - nature.com
Increasing evidence imputes cancer progression and resistance to therapy to intra-tumor
molecular heterogeneity set off by cancer cell plasticity. Re-activation of developmental …

[HTML][HTML] Lipid metabolism-related gene prognostic index (LMRGPI) reveals distinct prognosis and treatment patterns for patients with early-stage pulmonary …

A Jiang, X Chen, H Zheng, N Liu, Q Ding… - … Journal of Medical …, 2022 - ncbi.nlm.nih.gov
Background: Lipid metabolism plays a pivotal role in cancer progression and metastasis.
This study aimed to investigate the prognostic value of lipid metabolism-related genes …

A Signature Constructed Based on the Integrin Family Predicts Prognosis and Correlates with the Tumor Microenvironment of Patients with Lung Adenocarcinoma

S Zhang, D Liu, X Ning, X Zhang, Y Lu… - Journal of …, 2023 - dl.begellhouse.com
As an important element in regulating the tumor microenvironment (TME), integrin plays a
key role in tumor progression. This study aimed to establish prognostic signatures to predict …

Development and validation of an immune‐related gene signature for prognosis in Lung adenocarcinoma

Z Guo, X Qi, Z Li, J Yang, Z Sun, P Li… - IET Systems …, 2023 - Wiley Online Library
The most common type of lung cancer tissue is lung adenocarcinoma. The TCGA‐LUAD
cohort retrieved from the TCGA dataset was considered the internal training cohort, while …

In-depth characterization of a novel aggressive subtype of lung cancer and dissection of exosomal-miRNAs as key-players for early identification

F Mazzarelli - 2023 - iris.uniroma1.it
Lung adenocarcinoma (LUAD) is the most common type of non-small-cell lung cancer, and
a subset of patients with early-stage LUAD experience relapses and adverse prognosis …