Blood platelets and sepsis pathophysiology: a new therapeutic prospect in critical ill patients?
A Dewitte, S Lepreux, J Villeneuve, C Rigothier… - Annals of intensive …, 2017 - Springer
Beyond haemostasis, platelets have emerged as versatile effectors of the immune response.
The contribution of platelets in inflammation, tissue integrity and defence against infections …
The contribution of platelets in inflammation, tissue integrity and defence against infections …
Chronic kidney disease as a systemic inflammatory syndrome: update on mechanisms involved and potential treatment
Chronic kidney disease (CKD) is characterized by manifestations and symptoms involving
systemic organs and apparatus, associated with elevated cardiovascular morbidity and …
systemic organs and apparatus, associated with elevated cardiovascular morbidity and …
TNF‐α/HMGB1 inflammation signalling pathway regulates pyroptosis during liver failure and acute kidney injury
Y Wang, H Zhang, Q Chen, F Jiao, C Shi… - Cell …, 2020 - Wiley Online Library
Objective Acute kidney injury (AKI) is a common complication of acute liver failure (ALF).
Pyroptosis is a necrosis type related to inflammation. This study aimed to investigate the role …
Pyroptosis is a necrosis type related to inflammation. This study aimed to investigate the role …
Exosome‐mediated pyroptosis of miR‐93‐TXNIP‐NLRP3 leads to functional difference between M1 and M2 macrophages in sepsis‐induced acute kidney injury
CX Juan, Y Mao, Q Cao, Y Chen… - Journal of cellular …, 2021 - Wiley Online Library
Sepsis is a systemic inflammatory response syndrome caused by infection, resulting in
organ dysfunction. Sepsis‐induced acute kidney injury (AKI) is one of the most common …
organ dysfunction. Sepsis‐induced acute kidney injury (AKI) is one of the most common …
[HTML][HTML] Sepsis-mediated renal dysfunction: pathophysiology, biomarkers and role of phytoconstituents in its management
Sepsis has evolved as an enormous health issue amongst critically ill patients. It is a major
risk factor that results in multiple organ failure and shock. Acute kidney injury (AKI) is one of …
risk factor that results in multiple organ failure and shock. Acute kidney injury (AKI) is one of …
Kidney targeting peptide-modified biomimetic nanoplatforms for treatment of acute kidney injury
Z Huang, C Chun, X Li - Journal of Controlled Release, 2023 - Elsevier
The management of acute kidney injury (AKI) imposes a significant medical burden. Due to
the lack of effective drug transport vehicles, the administration of therapeutic agents for AKI …
the lack of effective drug transport vehicles, the administration of therapeutic agents for AKI …
Disseminated intravascular coagulation is strongly associated with severe acute kidney injury in patients with septic shock
J Helms, H Merdji, S Loewert, F Severac… - Annals of Intensive …, 2023 - Springer
Background Disseminated intravascular coagulation (DIC) worsens the prognosis of septic
shock and contributes to multiple organ failure. To date, no data linking DIC and acute …
shock and contributes to multiple organ failure. To date, no data linking DIC and acute …
NLRP3 inflammasome inhibition attenuates sepsis-induced platelet activation and prevents multi-organ injury in cecal-ligation puncture
DC Cornelius, OK Travis, RW Tramel… - PLoS …, 2020 - journals.plos.org
Sepsis is characterized by organ dysfunction due to a dysregulated immune response to
infection. Currently, no effective treatment for sepsis exists. Platelets are recognized as …
infection. Currently, no effective treatment for sepsis exists. Platelets are recognized as …
[HTML][HTML] Acute kidney injury in acute-on-chronic liver failure is different from in decompensated cirrhosis
AIM To evaluate the differences in acute kidney injury (AKI) between acute-on-chronic liver
failure (ACLF) and decompensated cirrhosis (DC) patients. METHODS During the period …
failure (ACLF) and decompensated cirrhosis (DC) patients. METHODS During the period …
NLRP 3 inflammasome activation in platelets in response to sepsis
DC Cornelius, CH Baik, OK Travis, DL White… - Physiological …, 2019 - Wiley Online Library
Sepsis is a complex syndrome characterized by organ dysfunction and a dysregulated
immune host response to infection. There is currently no effective treatment for sepsis, but …
immune host response to infection. There is currently no effective treatment for sepsis, but …