Contribution of the intestinal microbiome and gut barrier to hepatic disorders

DM Chopyk, A Grakoui - Gastroenterology, 2020 - Elsevier
Intestinal barrier dysfunction and dysbiosis contribute to development of diseases in liver
and other organs. Physical, immunologic, and microbiologic (bacterial, fungal, archaeal …

Ischaemia reperfusion injury in liver transplantation: Cellular and molecular mechanisms

WA Dar, E Sullivan, JS Bynon, H Eltzschig… - Liver …, 2019 - Wiley Online Library
Liver disease causing end organ failure is a growing cause of mortality. In most cases, the
only therapy is liver transplantation. However, liver transplantation is a complex undertaking …

Hepatotoxic potentials of methotrexate: Understanding the possible toxicological molecular mechanisms

D Ezhilarasan - Toxicology, 2021 - Elsevier
Methotrexate (MTX) is one of the most effective and widely used drugs in the management of
autoimmune and dermatological diseases. Rheumatoid arthritis and psoriasis patients who …

[PDF][PDF] Mouse models of nonalcoholic steatohepatitis: toward optimization of their relevance to human nonalcoholic steatohepatitis

G Farrell, JM Schattenberg, I Leclercq, MM Yeh… - …, 2019 - Wiley Online Library
Nonalcoholic steatohepatitis (NASH) arises from a variable interplay between environmental
factors and genetic determinants that cannot be completely replicated in animals …

The mechanism underlying extrapulmonary complications of the coronavirus disease 2019 and its therapeutic implication

Q Ning, D Wu, X Wang, D Xi, T Chen, G Chen… - Signal transduction and …, 2022 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) is a highly transmissible disease
caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that poses a …

Fluorescent probe for the imaging of superoxide and peroxynitrite during drug-induced liver injury

L Wu, J Liu, X Tian, RR Groleau, SD Bull, P Li… - Chemical …, 2021 - pubs.rsc.org
Drug-induced liver injury (DILI) is an important cause of potentially fatal liver disease.
Herein, we report the development of a molecular probe (LW-OTf) for the detection and …

N-Acetylcysteine: A potential therapeutic agent for SARS-CoV-2

FL Poe, J Corn - Medical hypotheses, 2020 - Elsevier
COVID-19, a respiratory disease caused by severe acute respiratory syndrome coronavirus
2 (SARS-CoV-2), continues to spread across the globe. Predisposing factors such as age …

Alcoholic liver disease: alcohol metabolism, cascade of molecular mechanisms, cellular targets, and clinical aspects

R Teschke - Biomedicines, 2018 - mdpi.com
Alcoholic liver disease is the result of cascade events, which clinically first lead to alcoholic
fatty liver, and then mostly via alcoholic steatohepatitis or alcoholic hepatitis potentially to …

Pain management in thoracic surgery

K Marshall, K McLaughlin - Thoracic Surgery Clinics, 2020 - thoracic.theclinics.com
Thoracic surgery ranks as one of the most painful surgical procedures. Pain after these
procedures can be debilitating and lead to poor outcomes, including respiratory …

Loss of Sam50 in hepatocytes induces cardiolipin‐dependent mitochondrial membrane remodeling to trigger mtDNA release and liver injury

L Chen, J Dong, S Liao, S Wang, Z Wu, M Zuo… - …, 2022 - Wiley Online Library
Abstract Background and Aims Sam50, a key component of the sorting and assembly
machinery (SAM) complex, is also involved in bridging mitochondrial outer‐membrane and …