The peripheral nervous system can be vulnerable to the toxic action of several drugs since it
is not protected as effectively as the central nervous system from noxious exogenous agents …

Commonly used chemotherapeutic agents in oncology/hematology practice, causing toxic
peripheral neuropathy, include taxanes, platinum compounds, vinca alkaloids, proteasome …

Purpose To provide evidence-based recommendations to update the American Society of
Clinical Oncology guideline on systemic therapy for stage IV non–small-cell lung cancer …

The taxanes (paclitaxel and docetaxel) represent an important class of antineoplastic agents
that interfere with microtubule function leading to altered mitosis and cellular death …

Docetaxel (Taxotere®) has been one of the most important chemotherapeutic drugs for
cancer treatment since 1996. Although a large number of clinical studies have been …

We develop methodology for a multistage-decision problem with flexible number of stages in
which the rewards are survival times that are subject to censoring. We present a novel Q …

Metastatic non-small-cell lung cancer (NSCLC) is the leading cause of cancer mortality in
Canada. Although treatment outcomes in advanced disease remain modest, with paradigm …

BACKGROUND: Treatment decisions for advanced non-small cell lung cancer (NSCLC) are
complex and require trade-offs between the benefits and risks experienced by patients. We …

The synthetic investigation of biologically active natural compounds serves two main
purposes:(i) the total synthesis of alkaloids and their analogues;(ii) modification of the …

Nowadays, lung cancer, as a health problem in worldwide, has high mortality both in men
and women. Despite advances in diagnosis and surgical techniques of lung cancer in recent …