Chronic pain is associated with persistent structural and functional changes throughout the
neuroaxis, including in the prefrontal cortex (PFC). The PFC is important in the integration of …

Aging and neurodegenerative diseases are frequently associated with the disruption of the
extracellular microenvironment, which includes mesenchyme and body fluid components …

The quest to comprehend genetic, biological, and symptomatic heterogeneity underlying
Alzheimer's disease (AD) requires a deep understanding of mechanisms affecting complex …

Microglia‐mediated neuroinflammation is one of the most remarkable hallmarks of
neurodegenerative diseases (NDDs), including AD, PD, and ALS. Accumulating evidence …

Epigenetics (particularly DNA methylation) together with environmental and genetic factors,
are key to understanding the pathogenesis of many diseases including dementia …

Neurodegenerative disorders are consequences of the deterioration of cells and tissues with
a mature undesirable way of life. The degenerative disease like Parkinson's disease (PD) …

DNA methylation at CpG sites is an essential epigenetic mark that regulates gene
expression during mammalian development and diseases. Methylome refers to the entire …

Background: Pathological amyloid-β and α-synuclein are associated with a spectrum of
related dementias, ranging from Alzheimer's disease (AD) and dementia with Lewy bodies …

Emerging evidence indicates that resolution of inflammation is a critical and dynamic
endogenous process for host tissues defending against external invasive pathogens or …

In order to conduct early therapeutic interventions for Alzheimer's disease (AD), convenient,
early diagnosis markers are required. We previously reported that changes in DNA …