Lewy body dementia encompasses both dementia with Lewy bodies and Parkinson's
disease dementia. Although both are common causes of dementia, they remain relatively …

Abstract Purpose of Review Although genome-scale studies have identified many genetic
variants associated with dementia, these do not account for all of disease incidence and so …

Environmentally sensitive molecular mechanisms in the brain, such as DNA methylation,
have become a significant focus of neuroscience research because of mounting evidence …

Introduction Inheritance of the ε4 allele of apolipoprotein E (APOE) increases a person's risk
of developing both Alzheimer's disease (AD) and Lewy body dementia (LBD), yet the …

Age is a major risk factor for neurodegenerative diseases like Parkinson's disease, but few
studies have explored the contribution of key hallmarks of aging, namely DNA methylation …

The pathogenesis of inflammatory bowel diseases (IBD) involves genetic predisposition,
environmental factors, and a broadly dysregulated intestinal immune response to the …

Abstract Kir4. 1, a glial‐specific inwardly rectifying potassium channel, is implicated in
astrocytic maintenance of K+ homeostasis. Underscoring the role of Kir4. 1 in central …

Background Epigenetic changes, such as DNA methylation, are observed in response to
environmental exposure and in the development of several chronic diseases. Consequently …

The common features of all neurodegenerative diseases, including Alzheimer's disease,
Parkinson's disease, Amyotrophic Lateral Sclerosis (ALS), and Huntington's disease, are the …

Abstract Background Neurodegenerative diseases (NGDs) such as Alzheimer's and
Parkinson's are debilitating and largely untreatable conditions strongly linked to age. The …