Machado-Joseph disease (MJD) is an autosomal dominant spinocerebellar ataxia (SCA)
caused by a polyglutamine expansion in the ataxin-3 protein, which initiates a cascade of …

Featured Application N/A. Abstract People who suffer a mild traumatic brain injury (mTBI)
have heterogeneous symptoms and disease trajectories, which make it difficult to precisely …

In previous research, voltage-dependent anion channel protein 2 (VDAC2) and the receptor
of activated protein C kinase 1 (RACK1) in flounder (Paralichthys olivaceus) were confirmed …

Background: Lewy-related pathology (LRP), primarily comprised of α-synuclein, is a typical
neuropathological change that has been identified in many neurodegenerative disorders …

This chapter primarily focuses on two key aspects related to aluminum neurotoxicity and its
mechanism in Alzheimer's disease (AD), which are genetic susceptibility and epigenetic …

Covalent modification of DNA via deposition of a methyl group at the 5′ position on
cytosine residues alters the chemical groups available for interaction in the major groove of …

Aims Multiple system atrophy (MSA) is a fatal neurodegenerative disease. Similar to
Parkinson's disease (PD), MSA is an α‐synucleinopathy, and its pathological hallmark …

Lifestyle-related phenotypes have been shown to be heritable and associated with DNA
methylation. We aimed to investigate whether genetic predisposition to tobacco smoking …

Nucleic acid modifications play important roles in biological activities and disease
occurrences, and have been considered as cancer biomarkers. Due to the relatively low …

Age remains the largest risk factor in the development of neurodegenerative diseases such
as Alzheimer's disease (AD). Numerous cellular hallmarks of aging contribute to the …