The release of transmitters at sympathoeffector junctions is not constant, but subject to
modulation by a plethora of different mechanisms. In this respect, presynaptic receptors …

Heart failure is the common concluding pathway for a majority of cardiovascular diseases
and is associated with cardiac dysfunction. Since heart failure is invariably preceded by …

Objectives: To assess the influence of the serotonin transporter variable number of tandem
repeat (HTT-VNTR) polymorphism and the serotonin transporter-gene-linked polymorphic …

The protective effects of sarpogrelate (SG), a 5-HT 2A antagonist, were investigated in
perfused guinea-pig Langendorff hearts subjected to ischemia and reperfusion. Changes in …

Background: It has been shown that serotonin (5-hydroxytryptamine, 5-HT) is involved in
exacerbating vascular abnormalities; however, its role in mediating changes in cardiac …

Recent evidence from our laboratory and others have suggested that the mechanism for a
decrease in resting blood pressure after an acute bout of exercise is a centrally mediated …

Orthostatic hypotension either because of autonomic failure or neurocardiogenic syncope
can be very incapacitating and should be treated accordingly. Drug therapy is frequently …

The sodium/proton exchanger type 1 (NHE-1) plays an important role in the proliferation of
vascular smooth muscle cells (VSMC). We have examined the regulation of NHE-1 by two …

Studies in our laboratory indicate that the 5-HT 1A agonist 8-OH DPAT acts in the central
nervous system at postsynaptic receptor sites to inhibit sympathetic nerve activity and lower …

1 The effects of 5‐hydroxytryptamine (5‐HT) and of the 5‐HT1‐like receptor agonists, 5‐
carboxamidotryptamine (5‐CT) and sumatriptan (GR43175) were investigated in isolated …