This paper is the 28th consecutive installment of the annual review of research concerning
the endogenous opioid system, now spanning over a quarter-century of research. It …

Objective To synthesize the current evidence for subcutaneous hydration and medication
infusions from systematic reviews and to assess their methodological quality. Introduction …

Both drug delivery performance and various age-related physical, mental and physiological
changes can affect drug effectiveness and safety in elderly patients. The many drug delivery …

Background In end-of-life care, symptoms of discomfort are mainly managed by drug
therapy, the guidelines for which are mainly based on expert opinions. A few papers have …

Context Especially in palliative care, safe and manageable administration of medication is
essential. Subcutaneous drug administration is a possible alternative, when oral intake is …

Purpose The undesired effects of midazolam can be life-threatening. This paper delineates
the findings related to the pharmacokinetics, adverse effects and drug-drug interactions as …

Objectives To describe the rationale for subcutaneous (SC) administration of antibiotics from
available published data and to make propositions to help clinicians in daily practice …

To evaluate the tolerability and clinical effects of subcutaneous (SC) levetiracetam for the
treatment of epileptic seizures in a palliative care setting, we conducted a retrospective chart …

A national survey was performed to explore antibiotic prescription by the subcutaneous (sc)
route among French infectious diseases and geriatric practitioners. Among the participating …

Background/Objective although poorly documented, subcutaneous (SC) administration of
antibiotics is common practice in France especially in Geriatrics Departments. The aim of …