Clinical properties of atypical antipsychotics are based on their interaction with D2
dopamine receptor and serotonin 5‐HT1A and 5‐HT2A receptors. As a part of our research …

Analogs of nantenine were docked into a modeled structure of the human 5-HT2A receptor
using ICM Pro, GLIDE, and GOLD docking methods. The resultant docking scores were …

A graphics model of the human 5-HT6 receptor was constructed and automated docking
studies were performed. The model suggests that 5-HT6 antagonist arylsulfonyltryptamines …

Abstract Novel 5 H-thiazolo [3, 2-a] pyrimidin-5-one derivatives linked through an ethylene
bridge to various phenylpiperazine groups were prepared for evaluation as 5-HT 2A …

As a G-protein coupled receptor, the 5-hydroxytryptamine 2A (5-HT2A) receptor is known for
its critical role in the cognitive, behavioural and physiological functions, and thus is a primary …

Pharmacophore models for 5-HT2A receptor antagonists consist of two
aromatic/hydrophobic regions at a given distance from a basic amine. We have previously …

There are a sufficient number of theories about the nature of physiological effect, such us
receptor, neural, biochemical, physicochemical to quantum. All of them are true, because …

This report describes the effect of replacing the central basic amine present in many known
5-HT2A ligands with an aromatic residue. We targeted the isomeric phenethylpyridines 2 …

The synthesis and 5-HT2A receptor affinities of ring altered derivatives of spiro [9, 10-
dihydroanthracene]-9, 3′-pyrrolidine (4), a structurally unique tetracyclic 5-HT2A receptor …

Several pharmacophore models have been proposed for 5-HT2A serotonin receptor
antagonists. These typically consist of two aromatic/hydrophobic moieties separated by a …