Isatin, an endogenous nonpeptide biofactor: A review of its molecular targets, mechanisms of actions, and their biomedical implications

A Medvedev, O Buneeva, O Gnedenko, P Ershov… - Biofactors, 2018 - Wiley Online Library
Abstract Isatin (indole‐2, 3‐dione) is an oxidized indole. It is widely distributed in
mammalian tissues and body fluids, where isatin concentrations vary significantly from< 0.1 …

Rationally designed monoamine oxidase A‐activatable AIE molecular photosensitizer for the specific imaging and cellular therapy of tumors

Y Hu, SY Yin, W Liu, Z Li, Y Chen, J Li - Aggregate, 2023 - Wiley Online Library
Due to both the requirements of repeated complex organic synthesis and tedious
biochemical verification experiments for the screening of new photosensitizers, the …

Biomarker-activatable photosensitizers with aggregation-induced emission characteristics for photodynamic therapy

Q Yu, J Li, Y Yu, M Yan, D Xu, S Yin - Coordination Chemistry Reviews, 2024 - Elsevier
Photodynamic therapy (PDT) is a prominent strategy in contemporary oncology for its
potential to selectively eradicate cancer cells. However, the non-specific accumulation of …

Mitochondrial-targeted and near-infrared fluorescence probe for bioimaging and evaluating monoamine oxidase A activity in hepatic fibrosis

ZM Yang, QY Mo, JM He, DL Mo, J Li, H Chen… - ACS …, 2020 - ACS Publications
Monoamine oxidase A (MAO-A) is a promising diagnostic marker for cancer, depression,
Parkinson's disease, and liver disease. The fluorescence detection of MAO-A in living …

pH-Triggered mitochondria targeting fluorescent probe for detecting Monoamine Oxidases A in living cells

Y Shu, Y Liu, Y Gao, J Li - Sensors and Actuators B: Chemical, 2023 - Elsevier
Abstract Monoamine oxidase A (MAO-A) is involved in various diseases such as heart
failure (HF), prostate cancer (PCa), psychiatric disorders, etc. The precise sensing of MAO-A …

Yohimbine ameliorates lipopolysaccharide-induced acute kidney injury in rats

T Shimokawa, K Yoneda, M Yamagata… - European Journal of …, 2020 - Elsevier
Sepsis-induced acute kidney injury (AKI) is frequently observed in the intensive care unit.
We previously revealed that yohimbine, an α 2-adrenoceptor antagonist, has protective …

The combination of indirubin and isatin attenuates dextran sodium sulfate induced ulcerative colitis in mice

W Gao, L Zhang, X Wang, L Yu… - Biochemistry and Cell …, 2018 - cdnsciencepub.com
Indirubin and isatin have been used in the treatment of inflammatory diseases due to their
anti-inflammatory properties. This study aimed to evaluate the combined effect of indirubin …

[HTML][HTML] Monoamine Oxidase Contributes to Valvular Oxidative Stress: A Prospective Observational Pilot Study in Patients with Severe Mitral Regurgitation

R Șoșdean, MD Dănilă, LN Ionică… - International Journal of …, 2024 - mdpi.com
Monoamine oxidases (MAOs), mitochondrial enzymes that constantly produce hydrogen
peroxide (H2O2) as a byproduct of their activity, have been recently acknowledged as …

[HTML][HTML] Post-treatment with JP-1302 protects against renal ischemia/reperfusion-induced acute kidney injury in rats

T Shimokawa, H Tsutsui, T Miura, M Takama… - Journal of …, 2019 - Elsevier
Ischemia/reperfusion injury is the most common cause of acute kidney injury. We previously
revealed that pre-treatment with yohimbine or JP-1302 attenuated renal …

[HTML][HTML] The protective role of vagus nerve stimulation in ischemia-reperfusion injury

Q Zhang, L Zhang, G Lin, F Luo - Heliyon, 2024 - cell.com
Ischemia-reperfusion injury (IRI) encompasses the damage resulting from the restoration of
blood supply following tissue ischemia. This phenomenon commonly occurs in clinical …