Oxidative stress in malaria: potential benefits of antioxidant therapy
ARQ Gomes, N Cunha, ELP Varela… - International Journal of …, 2022 - mdpi.com
Malaria is an infectious disease and a serious public health problem in the world, with 3.3
billion people in endemic areas in 100 countries and about 200 million new cases each …
billion people in endemic areas in 100 countries and about 200 million new cases each …
Control of cytokine production by human fc gamma receptors: implications for pathogen defense and autoimmunity
LTC Vogelpoel, DLP Baeten, EC de Jong… - Frontiers in …, 2015 - frontiersin.org
Control of cytokine production by immune cells is pivotal for counteracting infections via
orchestration of local and systemic inflammation. Although their contribution has long been …
orchestration of local and systemic inflammation. Although their contribution has long been …
Microbial phagocytic receptors and their potential involvement in cytokine induction in macrophages
YL Fu, RE Harrison - Frontiers in immunology, 2021 - frontiersin.org
Phagocytosis is an essential process for the uptake of large (> 0.5 µm) particulate matter
including microbes and dying cells. Specialized cells in the body perform phagocytosis …
including microbes and dying cells. Specialized cells in the body perform phagocytosis …
Functional antibodies and protection against blood-stage malaria
Numerous efforts to understand the functional roles of antibodies demonstrated that they can
protect against malaria. However, it is unclear which antibody responses are the best …
protect against malaria. However, it is unclear which antibody responses are the best …
A Glycolipidated-liposomal peptide vaccine confers long-term mucosal protection against Streptococcus pyogenes via IL-17, macrophages and neutrophils
Mucosally active subunit vaccines are an unmet clinical need due to lack of licensed
immunostimulants suitable for vaccine antigens. Here, we show that intranasal …
immunostimulants suitable for vaccine antigens. Here, we show that intranasal …
Inflammasomes in host response to protozoan parasites
DS Zamboni, DS Lima‐Junior - Immunological reviews, 2015 - Wiley Online Library
Inflammasomes are multimeric complexes of proteins that are assembled in the host cell
cytoplasm in response to specific stress signals or contamination of the cytoplasm by …
cytoplasm in response to specific stress signals or contamination of the cytoplasm by …
Inducible mechanisms of disease tolerance provide an alternative strategy of acquired immunity to malaria
W Nahrendorf, A Ivens, PJ Spence - Elife, 2021 - elifesciences.org
Immunity to malaria is often considered slow to develop but this only applies to defense
mechanisms that function to eliminate parasites (resistance). In contrast, immunity to severe …
mechanisms that function to eliminate parasites (resistance). In contrast, immunity to severe …
Malaria inflammation by xanthine oxidase‐produced reactive oxygen species
Malaria is a highly inflammatory disease caused by Plasmodium infection of host
erythrocytes. However, the parasite does not induce inflammatory cytokine responses in …
erythrocytes. However, the parasite does not induce inflammatory cytokine responses in …
Atypical activation of dendritic cells by Plasmodium falciparum
Dendritic cells (DCs) are activated by pathogens to initiate and shape immune responses.
We found that the activation of DCs by Plasmodium falciparum, the main causative agent of …
We found that the activation of DCs by Plasmodium falciparum, the main causative agent of …
Plasmodium falciparum histidine-rich protein II compromises brain endothelial barriers and may promote cerebral malaria pathogenesis
Cerebral malaria (CM) is a disease of the vascular endothelium caused by Plasmodium
falciparum. It is characterized by parasite sequestration, inflammatory cytokine production …
falciparum. It is characterized by parasite sequestration, inflammatory cytokine production …