[HTML][HTML] A new genomic framework to categorize pediatric acute myeloid leukemia
Recent studies on pediatric acute myeloid leukemia (pAML) have revealed pediatric-specific
driver alterations, many of which are underrepresented in the current classification schemas …
driver alterations, many of which are underrepresented in the current classification schemas …
Pediatric acute myeloid leukemia: Insight into genetic landscape and novel targeted approaches
Acute myeloid leukemia (AML) is a very heterogeneous hematological malignancy that
accounts for approximately 20% of all pediatric leukemia cases. The outcome of pediatric …
accounts for approximately 20% of all pediatric leukemia cases. The outcome of pediatric …
[HTML][HTML] Epigenomic machinery regulating pediatric AML: Clonal expansion mechanisms, therapies, and future perspectives
U Chianese, C Papulino, W Megchelenbrink… - Seminars in Cancer …, 2023 - Elsevier
Acute myeloid leukemia (AML) is a heterogeneous disease with a genetic, epigenetic, and
transcriptional etiology mainly presenting somatic and germline abnormalities. AML …
transcriptional etiology mainly presenting somatic and germline abnormalities. AML …
[HTML][HTML] Soluble Hemojuvelin and Ferritin: Potential Prognostic Markers in Pediatric Hematopoietic Cell Transplantation
Simple Summary In children after intensive chemotherapy for acute leukemias (AL) or
undergoing hematopoietic cell transplantation (HCT), the prognostic impact of 12 serum iron …
undergoing hematopoietic cell transplantation (HCT), the prognostic impact of 12 serum iron …
[HTML][HTML] Molecular-targeted therapy of pediatric acute myeloid leukemia
P Obszański, A Kozłowska, J Wańcowiat… - Molecules, 2022 - mdpi.com
Acute myeloid leukemia (AML) accounts for approximately 15–20% of all childhood
leukemia cases. The overall survival of children with acute myeloid leukemia does not …
leukemia cases. The overall survival of children with acute myeloid leukemia does not …
[HTML][HTML] Panel-based RNA fusion sequencing improves diagnostics of pediatric acute myeloid leukemia
LM Hoffmeister, J Suttorp, C Walter, E Antoniou… - Leukemia, 2024 - nature.com
New methods like panel-based RNA fusion sequencing (RNA-FS) promise improved
diagnostics in various malignancies. We here analyzed the impact of RNA-FS on the initial …
diagnostics in various malignancies. We here analyzed the impact of RNA-FS on the initial …
Long‐term follow‐up of haploidentical haematopoietic stem cell transplantation in paediatric patients with high‐risk acute myeloid leukaemia: Report from a single …
L Bai, ZX Zhang, GH Hu, YF Cheng… - British Journal of …, 2024 - Wiley Online Library
Data from 200 children with high‐risk acute myeloid leukaemia who underwent their first
haploidentical haematopoietic stem cell transplantation (haplo‐HSCT) between 2015 and …
haploidentical haematopoietic stem cell transplantation (haplo‐HSCT) between 2015 and …
[HTML][HTML] AML under the scope: current strategies and treatment involving FLT3 inhibitors and venetoclax-based regimens
S Milnerowicz, J Maszewska, P Skowera… - International Journal of …, 2023 - mdpi.com
Acute myeloid leukemia (AML) is a disease that mainly affects elderly patients who are more
often unfit for intensive chemotherapy (median age of diagnosis is 68). The regimens …
often unfit for intensive chemotherapy (median age of diagnosis is 68). The regimens …
TCRαβ/CD19 cell–depleted HLA-haploidentical transplantation to treat pediatric acute leukemia: updated final analysis
P Merli, M Algeri, F Galaverna, V Bertaina, B Lucarelli… - Blood, 2024 - ashpublications.org
TCRαβ/CD19 cell depletion is a promising graft manipulation technique frequently used in
the context of human leukocyte antigen (HLA)–haploidentical hematopoietic stem cell …
the context of human leukocyte antigen (HLA)–haploidentical hematopoietic stem cell …
[HTML][HTML] Two-drug versus three-drug induction chemotherapy in pediatric acute myeloid leukemia: a randomized controlled trial
V Radhakrishnan, S Bakhshi, S Kayal, C Thampy… - Blood Cancer …, 2022 - nature.com
The benefit of three-drug induction chemotherapy over a two-drug induction has not been
evaluated in pediatric acute myeloid leukemia (AML). We, therefore, conducted a …
evaluated in pediatric acute myeloid leukemia (AML). We, therefore, conducted a …