[HTML][HTML] A new genomic framework to categorize pediatric acute myeloid leukemia

M Umeda, J Ma, T Westover, Y Ni, G Song… - Nature Genetics, 2024 - nature.com
Recent studies on pediatric acute myeloid leukemia (pAML) have revealed pediatric-specific
driver alterations, many of which are underrepresented in the current classification schemas …

Pediatric acute myeloid leukemia: Insight into genetic landscape and novel targeted approaches

N Tosic, I Marjanovic, J Lazic - Biochemical Pharmacology, 2023 - Elsevier
Acute myeloid leukemia (AML) is a very heterogeneous hematological malignancy that
accounts for approximately 20% of all pediatric leukemia cases. The outcome of pediatric …

[HTML][HTML] Epigenomic machinery regulating pediatric AML: Clonal expansion mechanisms, therapies, and future perspectives

U Chianese, C Papulino, W Megchelenbrink… - Seminars in Cancer …, 2023 - Elsevier
Acute myeloid leukemia (AML) is a heterogeneous disease with a genetic, epigenetic, and
transcriptional etiology mainly presenting somatic and germline abnormalities. AML …

[HTML][HTML] Soluble Hemojuvelin and Ferritin: Potential Prognostic Markers in Pediatric Hematopoietic Cell Transplantation

J Styczyński, A Słomka, M Łęcka, K Albrecht… - Cancers, 2023 - mdpi.com
Simple Summary In children after intensive chemotherapy for acute leukemias (AL) or
undergoing hematopoietic cell transplantation (HCT), the prognostic impact of 12 serum iron …

[HTML][HTML] Molecular-targeted therapy of pediatric acute myeloid leukemia

P Obszański, A Kozłowska, J Wańcowiat… - Molecules, 2022 - mdpi.com
Acute myeloid leukemia (AML) accounts for approximately 15–20% of all childhood
leukemia cases. The overall survival of children with acute myeloid leukemia does not …

[HTML][HTML] Panel-based RNA fusion sequencing improves diagnostics of pediatric acute myeloid leukemia

LM Hoffmeister, J Suttorp, C Walter, E Antoniou… - Leukemia, 2024 - nature.com
New methods like panel-based RNA fusion sequencing (RNA-FS) promise improved
diagnostics in various malignancies. We here analyzed the impact of RNA-FS on the initial …

Long‐term follow‐up of haploidentical haematopoietic stem cell transplantation in paediatric patients with high‐risk acute myeloid leukaemia: Report from a single …

L Bai, ZX Zhang, GH Hu, YF Cheng… - British Journal of …, 2024 - Wiley Online Library
Data from 200 children with high‐risk acute myeloid leukaemia who underwent their first
haploidentical haematopoietic stem cell transplantation (haplo‐HSCT) between 2015 and …

[HTML][HTML] AML under the scope: current strategies and treatment involving FLT3 inhibitors and venetoclax-based regimens

S Milnerowicz, J Maszewska, P Skowera… - International Journal of …, 2023 - mdpi.com
Acute myeloid leukemia (AML) is a disease that mainly affects elderly patients who are more
often unfit for intensive chemotherapy (median age of diagnosis is 68). The regimens …

TCRαβ/CD19 cell–depleted HLA-haploidentical transplantation to treat pediatric acute leukemia: updated final analysis

P Merli, M Algeri, F Galaverna, V Bertaina, B Lucarelli… - Blood, 2024 - ashpublications.org
TCRαβ/CD19 cell depletion is a promising graft manipulation technique frequently used in
the context of human leukocyte antigen (HLA)–haploidentical hematopoietic stem cell …

[HTML][HTML] Two-drug versus three-drug induction chemotherapy in pediatric acute myeloid leukemia: a randomized controlled trial

V Radhakrishnan, S Bakhshi, S Kayal, C Thampy… - Blood Cancer …, 2022 - nature.com
The benefit of three-drug induction chemotherapy over a two-drug induction has not been
evaluated in pediatric acute myeloid leukemia (AML). We, therefore, conducted a …