The impact of sex and gender on stroke

KM Rexrode, TE Madsen, AYX Yu, C Carcel… - Circulation …, 2022 - Am Heart Assoc
Women face a disproportionate burden of stroke mortality and disability. Biologic sex and
sociocultural gender both contribute to differences in stroke risk factors, assessment …

Pravastatin, proton-pump inhibitors, metformin, micronutrients, and biologics: new horizons for the prevention or treatment of preeclampsia

S Tong, J Tu'uhevaha, R Hastie, F Brownfoot… - American journal of …, 2022 - Elsevier
There has been increasing research momentum to identify new therapeutic agents for the
prevention or treatment of preeclampsia, drugs that can affect the underlying disease …

Targeting oxidative stress and inflammation to prevent ischemia-reperfusion injury

L Wu, X Xiong, X Wu, Y Ye, Z Jian, Z Zhi… - Frontiers in molecular …, 2020 - frontiersin.org
The cerebral ischemia injury can result in neuronal death and/or functional impairment,
which leads to further damage and dysfunction after recovery of blood supply. Cerebral …

[HTML][HTML] Preeclampsia: linking placental ischemia with maternal endothelial and vascular dysfunction

BA Bakrania, FT Spradley, HA Drummond… - Comprehensive …, 2020 - ncbi.nlm.nih.gov
Preeclampsia (PE), a hypertensive disorder, occurs in 3% to 8% of pregnancies in the
United States and affects over 200,000 women and newborns per year. The United States …

Preeclampsia and cerebrovascular disease: the maternal brain at risk

EC Miller - Hypertension, 2019 - Am Heart Assoc
6 Hypertension July 2019 includes regulation of neurovascular coupling, the process by
which cerebral blood flow responds at the capillary level to increased neuronal metabolic …

Risk factors for pregnancy-associated stroke in women with preeclampsia

EC Miller, HJ Gatollari, G Too, AK Boehme, L Leffert… - Stroke, 2017 - Am Heart Assoc
Background and Purpose—Preeclampsia affects 3% to 8% of pregnancies and increases
risk of pregnancy-associated stroke (PAS). Data are limited on which women with …

Disruption of the blood-brain barrier by extracellular vesicles from preeclampsia plasma and hypoxic placentae: attenuation by magnesium sulfate

J León, J Acurio, L Bergman, J López… - …, 2021 - Am Heart Assoc
Preeclampsia, a pregnancy-related endothelial disorder, is associated with both
cardiovascular and cerebrovascular complications. Preeclampsia requires the presence of a …

Maternal stroke: a call for action

IY Elgendy, S Bukhari, AF Barakat, CJ Pepine… - Circulation, 2021 - Am Heart Assoc
Maternal mortality rates have been steadily increasing in the United States, and
cardiovascular mortality is the leading cause of death among pregnant and postpartum …

Neurology of preeclampsia and related disorders: an update in neuro-obstetrics

EC Miller, S Vollbracht - Current pain and headache reports, 2021 - Springer
Abstract Purpose of Review Preeclampsia and related hypertensive disorders of pregnancy
affect up to 10% of pregnancies. Neurological complications are common and neurologists …

Reliability of rodent and rabbit models in preeclampsia research

A Sakowicz, M Bralewska, P Kamola… - International Journal of …, 2022 - mdpi.com
In vivo studies on the pathology of gestation, including preeclampsia, often use small
mammals such as rabbits or rodents, ie, mice, rats, hamsters, and guinea pigs. The key …