Synaptic dysfunction connects autism spectrum disorder and sleep disturbances: A perspective from studies in model organisms

F Doldur-Balli, T Imamura, OJ Veatch, NN Gong… - Sleep medicine …, 2022 - Elsevier
Sleep disturbances (SD) accompany many neurodevelopmental disorders, suggesting SD is
a transdiagnostic process that can account for behavioral deficits and influence underlying …

Planthopper salivary sheath protein LsSP1 contributes to manipulation of rice plant defenses

HJ Huang, YZ Wang, LL Li, HB Lu, JB Lu… - Nature …, 2023 - nature.com
Salivary elicitors secreted by herbivorous insects can be perceived by host plants to trigger
plant immunity. However, how insects secrete other salivary components to subsequently …

Behavioral states

SW Flavell, DM Raizen, YJ You - Genetics, 2020 - academic.oup.com
Caenorhabditis elegans' behavioral states, like those of other animals, are shaped by its
immediate environment, its past experiences, and by internal factors. We here review the …

Variant-to-gene mapping followed by cross-species genetic screening identifies GPI-anchor biosynthesis as a regulator of sleep

J Palermo, A Chesi, A Zimmerman, S Sonti… - Science …, 2023 - science.org
Genome-wide association studies (GWAS) in humans have identified loci robustly
associated with several heritable diseases or traits, yet little is known about the functional …

Innate immunity promotes sleep through epidermal antimicrobial peptides

MP Sinner, F Masurat, JJ Ewbank, N Pujol… - Current Biology, 2021 - cell.com
Wounding and infection trigger a protective innate immune response that includes the
production of antimicrobial peptides in the affected tissue as well as increased sleep. Little is …

[HTML][HTML] A salt-induced kinase is required for the metabolic regulation of sleep

JJ Grubbs, LE Lopes, AM van der Linden… - PLoS …, 2020 - journals.plos.org
Many lines of evidence point to links between sleep regulation and energy homeostasis, but
mechanisms underlying these connections are unknown. During Caenorhabditis elegans …

ER proteostasis regulators cell-non-autonomously control sleep

T Kawano, M Kashiwagi, M Kanuka, CK Chen… - Cell Reports, 2023 - cell.com
Sleep is regulated by peripheral tissues under fatigue. The molecular pathways in
peripheral cells that trigger systemic sleep-related signals, however, are unclear. Here, a …

The neuropeptide receptor npr-38 regulates avoidance and stress-induced sleep in Caenorhabditis elegans

E Le, T McCarthy, M Honer, CE Curtin, J Fingerut… - Current Biology, 2023 - cell.com
Although essential and conserved, sleep is not without its challenges that must be
overcome; most notably, it renders animals vulnerable to threats in the environment …

Exploring the Potential of Lapatinib, Fulvestrant, and Paclitaxel Conjugated with Glycidylated PAMAM G4 Dendrimers for Cancer and Parasite Treatment

Ł Uram, K Wróbel, M Walczak, Ż Szymaszek… - Molecules, 2023 - mdpi.com
Fulvestrant (F), lapatinib (L), and paclitaxel (P) are hydrophobic, anticancer drugs used in
the treatment of estrogen receptor (ER) and epidermal growth factor receptor (EGFR) …

Sleep neuron depolarization promotes protective gene expression changes and FOXO activation

A Koutsoumparis, LM Welp, A Wulf, H Urlaub… - Current Biology, 2022 - cell.com
Sleep is an essential state that allows for recuperation and survival processes. Disturbing
sleep triggers stress responses that promote protective gene expression. Sleep and its …