Background Bladder cancer (BC) is the most common cancer of the urinary tract and
invariably predicts a poor prognosis. In this study, we found a reliable gene signature and …

Ovarian cancer is characterized by aberrant activation of the mitogen-activated protein
kinase (MAPK), highlighting the importance of targeting the MAPK pathway as an attractive …

Human cytomegalovirus (HCMV) is a significant cause of disease in immune-compromised
adults and immune naïve newborns. No vaccine exists to prevent HCMV infection, and …

Patients treated with dabrafenib/trametinib (DAB/TRA) exhibit a large interindividual
variability in clinical outcomes. The aims of this study were to characterize the …

Background Meningiomas are the most common primary brain tumor in adults, and somatic
loss of the neurofibromatosis 2 (NF2) tumor suppressor gene is a frequent genetic event …

Malignant peripheral nerve sheath tumors (MPNST) are aggressive soft-tissue sarcomas
which lack effective drugs. Loss of the RAS GTPase-activating protein NF1 and subsequent …

Background Peritoneal dissemination is a critical prognostic factor in ovarian cancer.
Although stabilized spheroid formation promotes cancer cell peritoneal dissemination in …

A" tug-of-war" between kinases and phosphatases establishes the phosphorylation states of
proteins. While serine and threonine phosphorylation can be catalyzed by more than 400 …

Purpose Alkaloids are naturally occurring chemical compounds that are widely distributed in
plants, and have pharmaceutical values and low toxicity. In recent years, some of them have …

Pancreatic ductal adenocarcinomas (PDAC) are deadly on account of the delay in diagnosis
and dearth of effective treatment options for advanced disease. The insurmountable hurdle …