Thioflavone derivatives are the thio analogs of the core constituent of the natural product
class of flavones. Based on the position and oxidation level of sulfur, they can be divided …

Mortality remains alarmingly high for patients diagnosed with pancreatic ductal
adenocarcinoma (PDAC), with 93% succumbing to the disease within five years. The vast …

The identification of dynamic protein phosphorylation events is critical for understanding
kinase/phosphatase‐regulated signaling pathways. To date, protein phosphorylation and …

Background Immune checkpoint inhibitors, along with BRAF and MEK inhibitors, have
dramatically changed the management of and outlook for patients with metastatic …

Simple Summary NRAS-mutant melanoma is a highly aggressive subtype with few treatment
options. Although both BRAF-mutant and NRAS-mutant melanomas have activation of the …

Aims Tumour heterogeneity and altered activation of signalling pathways play important
roles in therapy resistance. The PI3K/Akt/mTOR signalling network is a well-known regulator …

Targeted drugs aim to treat cancer by directly inhibiting oncogene activity or oncogenic
pathways, but drug resistance frequently emerges. Due to the intricate dynamics of cancer …

Triple-negative breast cancer (TNBC) is the most aggressive and deadly breast cancer
subtype. To date, chemotherapy is the only systemic therapy and prognosis remains poor …

The study is aimed at exploring the potential biological process and molecular mechanism
of KIF22 involved in the development and progression of pancreatic cancer. First, we used …

Kin17 DNA and RNA binding protein (Kin17) is a highly conserved protein that participates
in DNA replication, DNA repair and cell cycle progression. Recently, the tumor‑promoting …