Extraneural metastatic disease of glioma is rare and poses unique therapeutic challenges.
Increasingly, the ability to sequence genetic alterations in tumors has allowed for the …

Over half of BRAFV600E melanomas display intrinsic resistance to BRAF inhibitors, in part
due to adaptive signaling responses. In this communication we ask whether BRAFV600E …

More than ten thousand peer‐reviewed studies have assessed the role of fibroblast growth
factors (FGFs) and their receptors (FGFRs) in cancer, but few patients have yet benefited …

Although progress has been made in the treatment of cancer, particularly for the four major
types of cancers affecting the lungs, colon, breast and prostate, resistance to cancer …

Purpose Plexiform neurofibromas (pNF) are pathognomonic nerve and soft tissue tumors of
neurofibromatosis type I (NF1), which are highly resistant to conventional chemotherapy and …

Formononetin (FT) is a natural phytoestrogen isolated from red clover (Trifolium pratense L.).
Growing evidences indicate that FT-mediated cell arrest in cancers in vitro. However …

Introduction. The pharmacological treatment of cancer has evolved from cytotoxic to
molecular targeted therapy. The median survival gains of 124 drugs approved by the FDA …

Atractylenolide II (AT-II), the major bioactive compound of Atractylodes macrocephala,
exhibits anti-cancer activity against many types of tumors, but the roles and the potential …

Simple Summary Squamous cell carcinoma (SCC) is the most prevalent type of human
cancer worldwide and represents the majority of head and neck tumors. As SCC from …

Abstract Background MicroRNAs (miRNAs or miRs) are highly conserved non-coding RNAs
with a short length (18–24 nucleotides) that directly bind to a complementary sequence …