Purpose: Oral cancer causes considerable mortality across the globe, mainly due
development of chemoresistance and lack of efficient chemotherapeutic agents. In the …

Aberrant activity of oncogenic rat sarcoma virus (RAS) protein promotes tumor growth and
progression. RAS-driven cancers comprise more than 30% of all human cancers and are …

Melanoma is one of the deadliest skin cancers having a five-year survival rate around 15–
20%. An overactivated MAPK/AKT pathway is well-established in BRAF mutant melanoma …

α-Mangostin is a natural product commonly used in Asia for cosmetic and medicinal
applications including topical treatment of acne and skin cancer. Towards finding new …

Locally advanced squamous cell carcinoma of the head and neck (SCCHN) that is not
associated with human papillomavirus (HPV) has a poor prognosis in contrast to HPV …

Neurofibromatosis Type 1 (NF1)-related Malignant Peripheral Nerve Sheath Tumors
(MPNST) are highly resistant sarcomas that account for significant mortality. The …

Combination of MEK inhibitor and 5-FU had showed limited efficacy in clinical trials. We
previously reported that acquired resistance to 5-FU was related with continued activation of …

Xanthoxyletin Inhibits Proliferation of Human Oral Squamous Carcinoma Cells and Induces
Apoptosis, Autophagy, and Cell Cycle Arrest by Modulation of the MEK/ERK Signaling Pathway …

Introduction Targeted cancer therapeutics have demonstrated more limited clinical efficacy
than anticipated, due to both intrinsic and acquired drug resistance. Underlying mechanisms …

Otitis media (OM) is the most common bacterial infection in children. It remains a major
health problem and a substantial socioeconomic burden. Streptococcus pneumoniae (S …