Nanotechnological Approaches for the Treatment of Triple-Negative Breast Cancer: A Comprehensive Review
Breast cancer is the most prevalent cancer in women around the world, having a sudden
spread nowadays because of the poor sedentary lifestyle of people. Comprising several …
spread nowadays because of the poor sedentary lifestyle of people. Comprising several …
BRAF and MEK inhibitor therapy eliminates Nestin‐expressing melanoma cells in human tumors
DB Doxie, AR Greenplate… - Pigment cell & …, 2018 - Wiley Online Library
Little is known about the in vivo impacts of targeted therapy on melanoma cell abundance
and protein expression. Here, 21 antibodies were added to an established melanoma mass …
and protein expression. Here, 21 antibodies were added to an established melanoma mass …
[HTML][HTML] Hyperactive ERK and persistent mTOR signaling characterize vemurafenib resistance in papillary thyroid cancer cells
EK Hanly, NY Tuli, RB Bednarczyk, R Suriano… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Clinical studies evaluating targeted BRAFV600E inhibitors in advanced thyroid cancer
patients are currently underway. Vemurafenib (BRAFV600E inhibitor) monotherapy has …
patients are currently underway. Vemurafenib (BRAFV600E inhibitor) monotherapy has …
Drug Resistance and Novel Targets for Cancer Therapy: An Overview of Recent Findings
G Ouverney, D Hottz, BK Robbs - Biomedicines, 2024 - mdpi.com
The complex nature of cancer cells poses a challenge to the scientific community. Intrinsic
and acquired resistance mechanisms are implied in non-responsive initial cancer treatment …
and acquired resistance mechanisms are implied in non-responsive initial cancer treatment …
MicroRNA‐based therapeutic strategies for targeting mutant and wild type RAS in cancer
SB Sharma, JM Ruppert - Drug development research, 2015 - Wiley Online Library
ABSTRACT Preclinical Research MicroRNAs (miRs) have been causally implicated in the
progression and development of a wide variety of cancers. miRs modulate the activity of key …
progression and development of a wide variety of cancers. miRs modulate the activity of key …
Affinity-based profiling of endogenous phosphoprotein phosphatases by mass spectrometry
BL Brauer, K Wiredu, S Mitchell, GB Moorhead… - Nature protocols, 2021 - nature.com
Abstract Phosphoprotein phosphatases (PPPs) execute> 90% of serine/threonine
dephosphorylation in cells and tissues. While the role of PPPs in cell biology and diseases …
dephosphorylation in cells and tissues. While the role of PPPs in cell biology and diseases …
Role and Function of Receptor Tyrosine Kinases in BRAF Mutant Cancers
B Biersack, L Tahtamouni, M Höpfner - Receptors, 2024 - mdpi.com
The development of potent BRAF inhibitors has revolutionized the treatment of BRAF mutant
cancers, in particular, melanomas. However, BRAF mutant cancers of other entities, eg …
cancers, in particular, melanomas. However, BRAF mutant cancers of other entities, eg …
Quercetin increases mitochondrial proteins (VDAC and SDH) and downmodulates AXL and PIM-1 tyrosine kinase receptors in NRAS melanoma cells
KJP Rocha-Brito, SP Clerici, HG Cordeiro… - Biological …, 2022 - degruyter.com
Melanoma is a type of skin cancer with low survival rates after it has metastasized. In order
to find molecular differences that could represent targets of quercetin in anti-melanoma …
to find molecular differences that could represent targets of quercetin in anti-melanoma …
Kinobead profiling reveals reprogramming of BCR signaling in response to therapy within primary CLL cells
AJ Linley, LI Karydis, AK Mondru, A D'Avola… - Clinical Cancer …, 2021 - AACR
Purpose: B-cell receptor (BCR) signaling is critical for the pathogenesis of chronic
lymphocytic leukemia (CLL), promoting both malignant cell survival and disease …
lymphocytic leukemia (CLL), promoting both malignant cell survival and disease …
Novel imidazo [2, 1-b] oxazole derivatives inhibit epithelial cell transformation and triple negative breast cancer tumorigenesis
PY Bhattarai, CH Oh, G Kim, MS Kim, BS Lee… - Anticancer …, 2020 - ar.iiarjournals.org
Background/Aim: Triple negative breast cancer (TNBC) is an aggressive type of breast
cancer with limited targets for chemotherapy. This study evaluated the inhibitory effects of …
cancer with limited targets for chemotherapy. This study evaluated the inhibitory effects of …