Multicomponent reactions (MCRs) are one-pot reactions employing more than two starting
materials, for example, 3, 4,..., 7, where most of the atoms of the starting materials are …

TMEM16 proteins, also known as anoctamins, are involved in a variety of functions that
include ion transport, phospholipid scrambling, and regulation of other membrane proteins …

The calcium-activated chloride channel anoctamin 1 (ANO1) is located within the 11q13
amplicon, one of the most frequently amplified chromosomal regions in human cancer, but …

Diarrhoeal disease remains a major health burden worldwide. Secretory diarrhoeas are
caused by certain bacterial and viral infections, inflammatory processes, drugs and genetic …

Chloride channels represent a relatively under-explored target class for drug discovery as
elucidation of their identity and physiological roles has lagged behind that of many other …

TMEM16A (ANO1) functions as a calcium-activated chloride channel (CaCC). We
developed pharmacological tools to investigate the contribution of TMEM16A to CaCC …

Abstract The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …

Anoctamin1 (ANO1)/transmembrane protein 16A (TMEM16A), a calcium-activated chloride
channel (CaCC), is involved in many physiological functions such as fluid secretion, smooth …

There is an unmet need in severe asthma where approximately 40% of patients exhibit poor
β-agonist responsiveness, suffer daily symptoms and show frequent exacerbations …

TMEM16A (known as anoctamin 1) Ca 2+-activated chloride channel is overexpressed in
many tumors. TMEM16A overexpression can be caused by gene amplification in many …