Tumors are comprised of both cancer cells and surrounding stromal components. As an
essential part of the tumor microenvironment, the tumor stroma is highly dynamic …

Cancer microenvironment is critical for tumorigenesis and cancer progression. The
extracellular matrix (ECM) interacts with tumor and stromal cells to promote cancer cells …

As an important regulator of intracellular protein degradation, the mechanism of the
deubiquitinating enzyme family in tumour metastasis has received increasing attention. Our …

The tumor microenvironment (TME) has become the focus of interest in cancer research and
treatment. It includes the extracellular matrix (ECM) and ECM-modifying enzymes that are …

Modulation of the immune system is a critical part of anticancer therapies including
immunotherapy, chemotherapy, and radiotherapy. The aim of immunomodulation in cancer …

Breast cancer is a leading disease in women. Several studies are focused to evaluate the
critical role of extracellular matrix (ECM) in various biochemical and molecular aspects but …

Background. Collagen type V alpha 1 chain (COL5A1) is a hypoxia‐related gene (a
collagen family protein) and participates in the formation of the extracellular matrix. Although …

The mortality of patients with pancreatic ductal adenocarcinoma (PDAC) is strongly
associated with metastasis, a multistep process that is incompletely understood in this …

Collagens are the main components of extracellular matrix in the tumor microenvironment.
Both fibrillar and nonfibrillar collagens are involved in tumor progression. The nonfibrillar …

Ovarian cancer (OC) remains the leading cause of cancer‐related death among
gynecological cancers. The present study examined the role of collagen type V alpha 1 …