DNA topoisomerase II (topo II) is an important enzyme involved in DNA replication,
recombination, and repair. Despite the popular applications of topo II inhibitors in cancer …

In this paper, we report an efficient one-pot three-component reaction sequences comprising
Cu (I)-catalyzed 1, 3-dipolar cycloaddition (CuAAC) followed by Cu-catalyzed arylation of …

Cancer metabolism and epigenetics are among the most intensely pursued research areas
in anticancer drug discovery. Here we report the first small molecules that simultaneously …

Prostate cancer (PCa) is among the most commonly diagnosed solid cancers in male adults.
However, most anti-angiogenic therapies and immunotherapies fail to achieve durable …

Abstract Introduction Natural products (NPs) play a crucial role in the development of
therapeutic drugs. However, it is still highly challenging to identify the targets of NPs …

It is a well-known phenomenon that natural products can serve as powerful drug leads to
generate new molecular entities with novel therapeutic utility. Evodiamine (Evo), a major …

The past decades have witnessed rapid development in organic synthesis via catalysis,
particularly the reactions through C–H bond functionalization. Transition metals such as Pd …

A new series of styrylquinolines was designed and synthesized as anticancer agents and
tubulin polymerization inhibitors. The in vitro anticancer activity of the synthesized quinolines …

In this paper, a series of novel 4-substituted coumarin derivatives were synthesized. Among
these compounds 34, 39, 40, 43, 62, 65, and 67 exhibited significant antiproliferative activity …

The tetrahydro-β-carboline (THBC) nucleus is a predominant feature of a vast array of
naturally occurring alkaloids. Most of these alkaloids have been found to exhibit significant …