Inspired by the natural product evodiamine, a novel antitumor indolopyrazinoquinazolinone
scaffold was designed by scaffold hopping. Structure–activity relationship studies led to the …

Diverse transformations of 2-alkylthiobenzamides have been established to synthesize 2, 3-
dihydrobenzothiazin-4-ones, benzoisothiazol-3-ones and 2-alkylthiobenzonitriles in the …

Studies in Natural Products Chemistry, Volume 79 covers the synthesis, testing and
recording of the medicinal properties of natural products, providing cutting-edge accounts of …

DNA Topoisomerases (Topos) are ubiquitous nuclear enzymes involved in regulating the
topological state of DNA and, in eukaryotic organisms, Topos can be classified into two …

Background and purpose Zuojin capsule (ZJC), a classical prescription, is outstanding in
improving the conditions of patients with gastrointestinal diseases and colorectal cancer …

The nutritional compound capsaicin is the major spicy ingredient of chili peppers. Although
traditionally associated with analgesic activity, recent studies have shown that capsaicin has …

An organocatalytic enantioselective Michael–Michael cascade reaction is developed for the
synthesis of chiral spirotetrahydrothiopyrans. This highly functionalized scaffold was …

Alkaloids, a category of natural products with ring structures and nitrogen atoms, include
most US Food and Drug Administration approved plant derived anti-cancer agents …

A concise, one-step route to produce 3, 3′-diindolylmethanes (DIMs) from simple indoles
and ketones or aldehydes is reported. The key step is the ready formation of indole …

A silver-catalyzed cascade cyclization reaction of isocyanides with sulfoxonium ylides has
been developed for the first time. This reaction provides a new and efficient method for the …