A great challenge in multi-targeting drug discovery is to identify drug-like lead compounds
with therapeutic advantages over single target inhibitors and drug combinations. Inspired by …

Chalcone, a natural structure, demonstrates many pharmacological activities including
anticancer, and one promising mechanism is to modulate the generation of ROS. It has been …

Topoisomerase has been found extremely high level of expression in hepatocellular
carcinoma (HCC) and proven to promote the proliferation and survival of HCC. Cancer …

Natural product evodiamine and its derivatives represent a promising class of multi-target
antitumor agents. However, the clinical development of these compounds has been …

Evodiamine (Evo) is a quinazolinocarboline alkaloid found in Evodia rutaecarpa and
exhibits moderate antiproliferative activity. Herein, we report using a scaffold-hopping …

Clinical use of phosphodiesterase-5 (PDE5) inhibitors is limited by several side effects due
to weak isoform selectivity. Herein, a unique allosteric pocket of PDE5 is identified by …

The combination of a three-component, solvent-free pyrrole synthesis performed under
mechanochemical conditions with a TMSOTf-catalyzed oxonium-mediated cyclization gave …

So far, relatively few small molecules have been reported to promote tubulin degradation.
Our previous studies have found that compound 2, a noncovalent colchicine-site ligand, was …

Autophagy and NLRP3 inflammasome were associated with the process of colitis. Drugs
targeting NLRP3 inflammasome and autophagy to treat colitis are absent, and they are …

Abstract β‐Carboline, a privileged scaffold in the alkaloid family, has a broad spectrum of
medicinal properties and is found in several commercial drugs, such as tadalafil …