Evodiamine has many biological activities. Herein, we synthesize 23 disubstituted
derivatives of N14-phenyl or the E-ring of evodiamine and conduct systematic structure …

The review aims to draw attention to the latest advances in the organoboron chemistry and
therapeutic use of organoboron compounds. The synthetic strategies towards boron …

Topoisomerases are DNA processing enzymes that relieve supercoiling (torsional strain) in
DNA, are necessary for normal cellular division, and act by nicking (and then religating) …

In order to improve the antitumor potency of the natural product evodiamine, novel boron-
containing evodiamine derivatives were designed by incorporating boronic acid and …

Strategy to Construct Polycyclic Scaffolds via Formal Azaâ•’Dielsâ•’Alder Reaction of
Dihydro╒β╒Carbo Page 1 Title: Strategy to Construct Polycyclic Scaffolds via Formal AzaDiels-Alder …

To explore antitumor agents with high efficiency and selectivity, two series of 16 H 2 S
donating evodiamine derivatives 8–12 were synthesized and characterized by 1 H NMR, 13 …

Natural product evodiamine is one of the most privileged scaffolds in drug discovery and is
suitable for derivatization, which can be conducted quickly for structure optimization and …

A potential three component reaction strategy has been devised to generate nature inspired
β-carboline N-fused pyrroles containing pyridine tethers. These scaffolds were afforded in …

Hydroxyevodiamine is a multitargeting antitumor lead compound with excellent in vitro
activity. However, its in vivo antitumor potency is rather limited, which has hampered its …

Gastric cancer represents a significant health burden worldwide. Previously, inspired by the
traditional Chinese medicine Wu-Chu-Yu to treat the spleen and stomach system for …