On the basis of synergistic effect between topoisomerase (Top) and histone deacetylase
(HDAC) inhibitors, a series of novel evodiamine-based Top/HDAC dual inhibitors were …

Evodiamine (EVO) is a major alkaloid compound extracted from the dry unripened fruit
Evodiae fructus (Evodia rutaecarpa Benth., Rutaceae). EVO has a variety of …

Elephantopus mollis (EM) is a traditional herbal medicine with multiple pharmacological
activities. However, the efficacy of EM in treating human leukemia is currently unknown. In …

Gastrointestinal tumor is an important factor threatening human health. Natural product-
based drug discovery is a popular paradigm for expanding the chemical space and …

Herein, we report a biomimetic oxidative coupling cyclization strategy for the highly efficient
functionalization of tetrahydrocarbolines (THCs). This process enables rapid access to …

The colchicine binding site of tubulin is a promising target for discovering novel antitumor
agents which exert the antiangiogenic effect and are not susceptible to multidrug resistance …

Natural products are important sources for the development of therapeutic medicine, among
which evodia fruit has a wide range of medicinal properties in traditional Chinese medicine …

Efficient access to evodiamine and its analogues is presented via Lewis acid catalysis. In
this reaction, three chemical bonds and two heterocyclic-fused rings are constructed in one …

Due to significant activity profile and natural abundance of β‐carboline containing alkaloids,
β‐carboline N‐fused imidazole derivatives were designed and iodine assisted efficient …

The first series of nitric oxide donating derivatives of evodiamine were designed and
prepared. NO releasing ability of all target derivatives was evaluated in BGC-823, Bel-7402 …