The colchicine binding site of tubulin is a promising target for discovering novel antitumour
agents. Previously, we identified 2-aryl-4-amide-quinoline derivatives displayed moderate …

The one-pot total synthesis of evodiamine and its analogues is achieved using a three-
component reaction. Through continuous biscyclization, various readily available substrates …

Synthesis of β-carboline based natural products and synthetic derivatives is one of the
frontier areas of research owing to their medicinal properties. It is envisaged that 3-formyl-9H …

Multicomponent reactions (MCRs) provide an alternative scheme for target synthesis, by
allowing fast and efficient synthetic target access based on its “one‐pot” character …

We demonstrate the iron-catalyzed intermolecular coupling of internal alkynes and
thiosalicylic acid derivatives. The reaction was effectively catalyzed by the Fe (acac) 2/1, 10 …

Silver-mediated intramolecular α-C (sp3)–H bond functionalization of the methylthio group
has been established in the presence of Selectfluor as an additive. This novel strategy …

A new fluorescent ribonucleoside alphabet (mthN) consisting of pyrimidine and purine
analogues, all derived from methylthieno [3, 4‐d] pyrimidine as the heterocyclic core, is …

An efficient protocol for the direct transformation of chroman-4-ones to tricyclic fused
pyridines with the skeleton of cassiarins, a family of alkaloids with antimalarial activity, was …

Nitrogen mustards, a family of DNA alkylating agents, marked the start of cancer
pharmacotherapy. While traditionally characterized by their dose-limiting toxic effects …

A series of novel 4-anilinoquinoline derivatives were synthesized and evaluated for their
antiproliferative activities. Among them, 14h exhibited the most potent cytotoxic activity with …