ApoE is the major lipid and cholesterol carrier in the CNS. There are three major human
polymorphisms, apoE2, apoE3, and apoE4, and the genetic expression of APOE4 is one of …

Aggregation of alpha-synuclein into inclusion bodies, termed Lewy pathology, is a defining
feature of Parkinson's disease (PD) and Dementia with Lewy bodies (DLB). In the majority of …

Abstract Coronavirus disease-2019 (COVID-19) is primarily a respiratory disease, however,
an increasing number of reports indicate that SARS-CoV-2 infection can also cause severe …

Amyloid proteins, which are considered 'villains' in many neurodegenerative diseases, form
enigmatic pathological strains that underlie disease pathogenesis and progression. Recent …

For the last two decades, pathogenic concepts in Parkinson disease (PD) have revolved
around the toxicity and spread of α-synuclein. Thus, α-synuclein would follow caudo-rostral …

The accumulation of protein inclusions is linked to many neurodegenerative diseases that
typically develop in older individuals, due to a combination of genetic and environmental …

Amyloid-forming proteins such α-synuclein and tau, which are implicated in Alzheimer's and
Parkinson's disease, can form different fibril structures or strains with distinct toxic properties …

Parkinson's disease (PD) is a neurodegenerative disorder characterized by the gradual loss
of dopaminergic neurons in the substantia nigra and the accumulation of α-synuclein …

Parkinson's disease (PD) is an age-related neurodegenerative disorder affecting millions of
people worldwide. The disease is characterized by the progressive loss of dopaminergic …

Exosomal release pathway and autophagy together maintain homeostasis and survival of
cells under stressful conditions. Autophagy is a catabolic process through which cell entities …