The role of Notch signaling pathway in metabolic bone diseases

Y Gao, Z Fu, J Guan, X Liu, Q Zhang - Biochemical Pharmacology, 2023 - Elsevier
Metabolic bone diseases is the third most common endocrine diseases after diabetes and
thyroid diseases. More than 500 million people worldwide suffer from metabolic bone …

Epigenetic regulation of bone mass

EM Curtis, NR Fuggle, C Cooper, NC Harvey - Best Practice & Research …, 2022 - Elsevier
Osteoporosis, characterised by low bone mass, poor bone structure, and an increased risk
of fracture, is a major public health problem. There is increasing evidence that the influence …

IL-17 promotes osteoclast-induced bone loss by regulating glutamine-dependent energy metabolism

R Peng, Y Dong, M Zheng, H Kang, P Wang… - Cell Death & …, 2024 - nature.com
Osteoclasts consume an amount of adenosine triphosphate (ATP) to perform their bone
resorption function in the development of osteoporosis. However, the mechanism underlying …

Emerging Role of 18F-NaF PET/Computed Tomographic Imaging in Osteoporosis: A Potential Upgrade to the Osteoporosis Toolbox

AJ Sheppard, SS Paravastu, NM Wojnowski… - PET clinics, 2023 - pet.theclinics.com
Osteoporosis is the most common metabolic bone disorder, with an estimated prevalence of
13.1% to 27.1% of women and 3.3% to 5.7% of men over the age of 50 affected. 1, 2 As a …

Rosavin regulates bone homeostasis through HDAC1-induced epigenetic regulation of EEF2

W Zhang, L Yu, F Wang, M Chen, H Li - Chemico-biological interactions, 2023 - Elsevier
Bioactive constituents from Rhodiola rosea L. show a myriad of pharmacological effects on
diverse diseases. Rosavin has been linked to reduced osteoclastogenesis, while its role in …

Effect of N-Vinyl-2-Pyrrolidone (NVP), a bromodomain-binding small chemical, on osteoblast and osteoclast differentiation and its potential application for bone …

VA Klemmer, N Khera, BM Siegenthaler… - International Journal of …, 2021 - mdpi.com
The human skeleton is a dynamic and remarkably organized organ system that provides
mechanical support and performs a variety of additional functions. Bone tissue undergoes …

Discovery of novel serum biomarkers for diagnosing and predicting postmenopausal osteoporosis patients by 4D‐label free protein omics

C Li, H Pan, W Liu, G Jin, W Liu… - Journal of …, 2023 - Wiley Online Library
We aimed to identify protein biomarkers that could rapidly and accurately diagnose
osteoporosis patients (OPs) using a highly sensitive proteomic immunoassay. Four …

[HTML][HTML] Epigenetic regulation of bone remodeling and its role in the pathogenesis of primary osteoporosis

BI Yalaev, RI Khusainova - Vavilov Journal of Genetics and …, 2023 - ncbi.nlm.nih.gov
Discovery of molecular mechanisms of primary osteoporosis development is fundamental to
understand the pathogenesis of musculoskeletal diseases in general and for identifying key …

Эпигенетическая регуляция ремоделирования костной ткани и ее роль в патогенезе первичного остеопороза

БИ Ялаев, РИ Хусаинова - Вавиловский журнал генетики и …, 2023 - vavilov.elpub.ru
Аннотация Раскрытие молекулярных механизмов развития первичного остеопороза
имеет фундаментальное значение как с точки зрения понимания патогенеза …