Cancer is at present one of the utmost deadly diseases worldwide. Past efforts in cancer
research have focused on natural medicinal products. Over the past decades, a great deal of …

Antibiotic resistance poses a tremendous threat to human health. To overcome this problem,
it is essential to know the mechanism of antibiotic resistance in antibiotic-producing and …

Computational approaches such as genome and metabolome mining are becoming
essential to natural products (NPs) research. Consequently, a need exists for an automated …

Berberine hydrochloride (BBR) is a natural product widely used in clinical medicine and
animal production. It has a variety of antimicrobial effects, but its complex antimicrobial …

The 2018 marine pharmacology literature review represents a continuation of the previous
11 reviews of a series initiated in 1998. Preclinical marine pharmacology research during …

The rationale of our bioprospecting campaigns is that the extremobiosphere, particularly the
deep sea and hyper-arid deserts, harbours undiscovered biodiversity that is likely to express …

Veterinary antibiotics such as sulfonamides are widely used to increase feed efficiency and
to protect against disease in livestock production. The sulfonamide antimicrobial mechanism …

Tetrahydropyrans (THPs) are common structural motifs found in natural products and
synthetic therapeutic molecules. In Nature these 6-membered oxygen heterocycles are often …

The title of this essay is as much a question as it is a statement. The discovery of the β-
lactam antibiotics—including penicillins, cephalosporins, and carbapenems—as largely (if …

Marine microorganisms live in dramatically different environments and have attracted much
attention for their structurally unique natural products with potential strong biological activity …