Eslicarbazepine acetate: a new improvement on a classic drug family for the treatment of partial-onset seizures
GL Galiana, AC Gauthier, RH Mattson - Drugs in R&D, 2017 - Springer
Eslicarbazepine acetate is a new anti-epileptic drug belonging to the dibenzazepine
carboxamide family that is currently approved as adjunctive therapy and monotherapy for …
carboxamide family that is currently approved as adjunctive therapy and monotherapy for …
Pharmacotherapy of epilepsy: newly approved and developmental agents
LJ Stephen, MJ Brodie - CNS drugs, 2011 - Springer
This article discusses seven newly available antiepileptic drugs (AEDs) and agents in phase
III development. Lacosamide, licensed as an adjunctive treatment for partial-onset seizures …
III development. Lacosamide, licensed as an adjunctive treatment for partial-onset seizures …
Long-term efficacy and safety from an open-label extension of adjunctive cenobamate in patients with uncontrolled focal seizures
Background and Objectives To evaluate long-term efficacy (percent seizure frequency
reduction and responder rates), safety, and tolerability of adjunctive cenobamate (CNB) in …
reduction and responder rates), safety, and tolerability of adjunctive cenobamate (CNB) in …
Eslicarbazepine and the enhancement of slow inactivation of voltage-gated sodium channels: a comparison with carbamazepine, oxcarbazepine and lacosamide
S Hebeisen, N Pires, AI Loureiro, MJ Bonifácio… - …, 2015 - Elsevier
This study aimed at evaluating the effects of eslicarbazepine, carbamazepine (CBZ),
oxcarbazepine (OXC) and lacosamide (LCM) on the fast and slow inactivated states of …
oxcarbazepine (OXC) and lacosamide (LCM) on the fast and slow inactivated states of …
Perampanel, a selective, noncompetitive α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid receptor antagonist, as adjunctive therapy for refractory partial …
Purpose: To evaluate safety, tolerability, and seizure outcome data during long‐term
treatment with once‐daily adjunctive perampanel (up to 12 mg/day) in patients with …
treatment with once‐daily adjunctive perampanel (up to 12 mg/day) in patients with …
Long‐term individual retention with cenobamate in adults with focal seizures: pooled data from the clinical development program
Objective We determined retention on open‐label cenobamate therapy in the clinical
development program to assess the long‐term efficacy and tolerability of adjunctive …
development program to assess the long‐term efficacy and tolerability of adjunctive …
Efficacy and safety of eslicarbazepine acetate versus controlled‐release carbamazepine monotherapy in newly diagnosed epilepsy: a phase III double‐blind …
Objective We assessed the efficacy and safety of once‐daily eslicarbazepine acetate in
comparison with twice‐daily (BID) controlled‐release carbamazepine (carbamazepine‐CR) …
comparison with twice‐daily (BID) controlled‐release carbamazepine (carbamazepine‐CR) …
Targeting pharmacoresistant epilepsy and epileptogenesis with a dual-purpose antiepileptic drug
A Doeser, G Dickhof, M Reitze, M Uebachs, C Schaub… - Brain, 2015 - academic.oup.com
In human epilepsy, pharmacoresistance to antiepileptic drug therapy is a major problem
affecting a substantial fraction of patients. Many of the currently available antiepileptic drugs …
affecting a substantial fraction of patients. Many of the currently available antiepileptic drugs …
Safety, tolerability, and seizure control during long‐term treatment with adjunctive brivaracetam for partial‐onset seizures
M Toledo, J Whitesides, J Schiemann, ME Johnson… - …, 2016 - Wiley Online Library
Objectives To report pooled safety/tolerability and seizure outcome data from adults with
uncontrolled partial‐onset (focal) seizures (POS) receiving adjunctive brivaracetam (BRV) …
uncontrolled partial‐onset (focal) seizures (POS) receiving adjunctive brivaracetam (BRV) …
Perampanel S tudy 207: long‐term open‐label evaluation in patients with epilepsy
I Rektor, GL Krauss, M Bar, V Biton… - Acta Neurologica …, 2012 - Wiley Online Library
Objectives Evaluate interim long‐term tolerability, safety and efficacy of adjunctive
perampanel, a novel α‐amino‐3‐hydroxy‐5‐methyl‐5‐isoxazolepropionic acid (AMPA) …
perampanel, a novel α‐amino‐3‐hydroxy‐5‐methyl‐5‐isoxazolepropionic acid (AMPA) …