A human intestinal M-cell-like model for investigating particle, antigen and microorganism translocation

A Beloqui, DJ Brayden, P Artursson, V Préat… - nature protocols, 2017 - nature.com
The specialized microfold cells (M cells) in the follicle-associated epithelium (FAE) of
intestinal Peyer's patches serve as antigen-sampling cells of the intestinal innate immune …

Recent advances in gold and silver nanoparticle based therapies for lung and breast cancers

P Malik, TK Mukherjee - International Journal of Pharmaceutics, 2018 - Elsevier
In recent years, gold (Au) and silver (Ag) nanoparticles (NPs) have been the centerstage of
improving cancer treatments and therapies, substantially attributed to their size and shape …

Targeting tumor highly-expressed LAT1 transporter with amino acid-modified nanoparticles: toward a novel active targeting strategy in breast cancer therapy

L Li, X Di, M Wu, Z Sun, L Zhong, Y Wang, Q Fu… - … , Biology and Medicine, 2017 - Elsevier
Designing active targeting nanocarriers with increased cellular accumulation of
chemotherapeutic agents is a promising strategy in cancer therapy. Herein, we report a …

Microfluidic manipulation of core/shell nanoparticles for oral delivery of chemotherapeutics: a new treatment approach for colorectal cancer

MM Hasani-Sadrabadi, S Taranejoo… - Advanced …, 2016 - epublications.marquette.edu
A microfluidics approach to synthesize core–shell nanocarriers with high pH tunability is
described. The sacrificial shell protects the core layer with the drugs and prevents their …

The optimized delivery of triterpenes by liposomal nanoformulations: Overcoming the challenges

A Milan, A Mioc, A Prodea, M Mioc, R Buzatu… - International journal of …, 2022 - mdpi.com
The last decade has witnessed a sustained increase in the research development of modern-
day chemo-therapeutics, especially for those used for high mortality rate pathologies …

Dextran–protamine coated nanostructured lipid carriers as mucus-penetrating nanoparticles for lipophilic drugs

A Beloqui, MÁ Solinís, A des Rieux, V Préat… - International journal of …, 2014 - Elsevier
The main objectives of the present study were (i) to evaluate the effect of the mucus layer on
saquinavir-loaded nanostructured lipid carriers (SQV-NLCs) uptake and (ii) to evaluate the …

Functionalized materials for multistage platforms in the oral delivery of biopharmaceuticals

F Araujo, J das Neves, JP Martins, PL Granja… - Progress in Materials …, 2017 - Elsevier
Recent developments in materials science and specific surface functionalization of materials
are providing new tools for the rational design of precisely engineered drug delivery …

Bioinspired butyrate-functionalized nanovehicles for targeted oral delivery of biomacromolecular drugs

L Wu, M Liu, W Shan, X Zhu, L Li, Z Zhang… - Journal of Controlled …, 2017 - Elsevier
Ligand-functionalization can increase the affinity of nanoparticles (NPs) with targeted cells.
However, one major defect of ligands still exists in oral administration: limited receptor …

[HTML][HTML] Biomimetic thiamine-and niacin-decorated liposomes for enhanced oral delivery of insulin

H He, Y Lu, J Qi, W Zhao, X Dong, W Wu - Acta Pharmaceutica Sinica B, 2018 - Elsevier
Biomimetic nanocarriers are emerging as efficient vehicles to facilitate dietary absorption of
biomacromolecules. In this study, two vitamins, thiamine and niacin, are employed to …

Airway epithelial-targeted nanoparticle reverses asthma in inhalation therapy

Y Yu, M Ni, Y Zheng, Y Huang - Journal of Controlled Release, 2024 - Elsevier
Despite extensive research on corticosteroids for treating asthma, their short residence time
in the lungs has limited their therapeutic effects in vivo. Nanoparticles have been widely …