Role of cholinergic signaling in Alzheimer's disease

ZR Chen, JB Huang, SL Yang, FF Hong - Molecules, 2022 - mdpi.com
Acetylcholine, a neurotransmitter secreted by cholinergic neurons, is involved in signal
transduction related to memory and learning ability. Alzheimer's disease (AD), a progressive …

Pharmacotherapy evolution in Alzheimer's disease: current framework and relevant directions

DC Miculas, PA Negru, SG Bungau, T Behl, SS Hassan… - Cells, 2022 - mdpi.com
Alzheimer's disease (AD), once considered a rare disease, is now the most common form of
dementia in the elderly population. Current drugs (cholinesterase inhibitors and glutamate …

[HTML][HTML] Diet and lifestyle impact the development and progression of Alzheimer's dementia

S Arora, JA Santiago, M Bernstein… - Frontiers in …, 2023 - ncbi.nlm.nih.gov
Dementia is a growing public health concern, with an estimated prevalence of 57 million
adults worldwide. Alzheimer's disease (AD) accounts for 60–80% of the cases. Clinical trials …

Identification of bioactive peptides from a Brazilian kefir sample, and their anti-Alzheimer potential in Drosophila melanogaster

SM Malta, LL Batista, HCG Silva, RR Franco… - Scientific Reports, 2022 - nature.com
Alzheimer's disease (AD) is the most common form of dementia in the elderly, affecting
cognitive, intellectual, and motor functions. Different hypotheses explain AD's mechanism …

[HTML][HTML] Therapeutic potential of natural molecules against Alzheimer's disease via SIRT1 modulation

M Zhang, Z Tang - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Alzheimer's disease (AD) is a neurodegenerative disease mainly characterized by
progressive cognitive dysfunction and memory impairment. Recent studies have shown that …

[HTML][HTML] From tryptophan-based amides to tertiary amines: Optimization of a butyrylcholinesterase inhibitor series

A Meden, D Knez, X Brazzolotto, F Nachon… - European journal of …, 2022 - Elsevier
Lead optimization of a series of tryptophan-based nanomolar butyrylcholinesterase (BChE)
inhibitors led to tertiary amines as highly potent, achiral, sp 3-rich analogues with better …

Dysregulated miRNAs in progression and pathogenesis of Alzheimer's disease

T Arora, V Prashar, R Singh, TS Barwal… - Molecular …, 2022 - Springer
Alzheimer's disease (AD) is a progressive degeneration of neurons due to the accumulation
of amyloid-β peptide (Aβ) and hyper-phosphorylation of tau protein in the neuronal milieu …

Role of Natural Compounds and Target Enzymes in the Treatment of Alzheimer's Disease

S Wang, X Kong, Z Chen, G Wang, J Zhang, J Wang - Molecules, 2022 - mdpi.com
Alzheimer's disease (AD) is a progressive neurological condition. The rising prevalence of
AD necessitates the rapid development of efficient therapy options. Despite substantial …

Mechanistic insights, treatment paradigms, and clinical progress in neurological disorders: Current and future prospects

S Alkahtani, NS Al-Johani, S Alarifi - International Journal of Molecular …, 2023 - mdpi.com
Neurodegenerative diseases (NDs) are a major cause of disability and are related to brain
development. The neurological signs of brain lesions can vary from mild clinical shortfalls to …

[HTML][HTML] 900áMHZ electromagnetic field exposure relieved AD-like symptoms on APP/PS1 mice: A potential non-invasive strategy for AD treatment

W Zhi, Y Zou, L Ma, S He, Z Guo, X Zhao, X Hu… - Biochemical and …, 2023 - Elsevier
Background Evidence shows that microwaves radiation may have various biological effects
on central nervous system. Role of electromagnetic fields in neurodegenerative diseases …