Dimethyl acetylenedicarboxylate (DMAD) is an electron-deficient acetylenic compound
having two reactive ester groups. It is a privileged and advantaged molecule, which …

Domino reactions have attracted much high attention in recent years due to its convergence,
productivity, facile execution and generation of highly diverse and complex products from …

2-pyridones represents ubiquitous scaffolds often present in both natural products and
pharmaceutical compounds. Due to their wide applications in medicinal chemistry, it is not …

Reaction of β-enaminones and acetylene dicarboxylates: synthesis of substituted 1,2-dihydropyridinones
- Organic & Biomolecular Chemistry (RSC Publishing) DOI:10.1039/C4OB01578A Royal …

A direct, one‐pot and regioselective access to N‐alkyl‐and N‐aryl‐substituted 2‐pyridones
is described from readily available β‐keto amides and either primary or secondary …

The synthesis of 1‐(2‐aminoethyl)‐6‐alkyl‐4‐polyfluoroalkylpyridin‐2‐ones based on the
acidic cleavage of 7‐hydroxy‐7‐polyfluoroalkylhexahydroimidazo [1, 2‐a] pyridin‐5‐ones is …

A general strategy for the conversion of [2.2. 2]-diazabicyclic alkene structures to 2-pyridone
aromatic heterocyclic products is reported. The reaction sequence starts from 2, 5 …

The one‐pot four‐component reaction of benzohydrazide, acetylenedicarboxylate, aromatic
aldehydes and malononitrile in ethanol with triethylamine as base catalyst afforded …

摘要串联反应具有原料简单易得, 中间产物无需分离提纯, 操作简单, 节省溶剂和降低消耗等很多
独特优点, 已成为当前有机合成研究的热点课题. 缺电子炔烃与芳香胺在温和条件下快速反应 …

A convenient and efficient annulation reaction was developed, affording 2-pyridones in good
to excellent yields. A variety of substituted β-keto amides and ynals were well tolerated, and …