[HTML][HTML] Small molecule TSC01682 inhibits osteosarcoma cell growth by specifically disrupting the CUL4B-DDB1 interaction and decreasing the ubiquitination of …
B Chen, Y Feng, M Zhang, G Cheng… - American Journal of …, 2019 - ncbi.nlm.nih.gov
The direct interaction between Cullin 4B (CUL4B) and DNA damage-binding protein 1
(DDB1) is required for the assembly of Cullin4B-RING E3 ligase complex (CRL4B), which …
(DDB1) is required for the assembly of Cullin4B-RING E3 ligase complex (CRL4B), which …
CUL4B regulates autophagy via JNK signaling in diffuse large B-cell lymphoma
Y Li, X Zhou, Y Zhang, J Yang, Y Xu, Y Zhao, X Wang - Cell Cycle, 2019 - Taylor & Francis
Aberrant expression of CUL4B was identified in various types of solid cancers. Cumulative
evidences support the oncogenic role of CUL4B in cancers, including regulation of cell …
evidences support the oncogenic role of CUL4B in cancers, including regulation of cell …
Association of CUL4B with the pathogenesis of age-related cataract
C Karaosmanoğlu, SH Yıldız, M Akdoğan… - International …, 2024 - Springer
Purpose Age-related cataract (ARC) is the most common cause of visual impairment and
blindness in older adults. However, the role of CUL4B in the ARC remains unclear …
blindness in older adults. However, the role of CUL4B in the ARC remains unclear …
[HTML][HTML] Embryonic Cul4b is important for epiblast growth and location of primitive streak layer cells
Cul4b-null (Cul4b Δ/Y) mice undergo growth arrest and degeneration during the early
embryonic stages and die at E9. 5. The pathogenic causes of this lethality remain …
embryonic stages and die at E9. 5. The pathogenic causes of this lethality remain …