In this study, we present a new protocol for kidney replacement therapy (hemodialysis),
based on an explicitly solvable mathematical model. With current protocols, the high and …

Recent studies have suggested benefits for time-dependent dialysate bicarbonate
concentrations (Dbic) during hemodialysis (HD). In this clinical trial, we compared for the first …

The acid-base goal of intermittent hemodialysis is to replenish buffers consumed by
endogenous acid production and expansion acidosis in the period between treatments. The …

Acid-base regulation by the kidneys is largely missing in end-stage renal disease patients
undergoing hemodialysis (HD). Bicarbonate is added to the dialysis fluid during HD to …

One important objective of the hemodialysis treatment is the neutralization of interdialytic
acid generation by transport of bicarbonate and other buffer bases from dialysis fluid to the …

TO THE EDITOR: Several years ago, we addressed the question of why blood bicarbonate
concentration ([HCO3 À]) fails to increase notably during the last half of a standard …

In bicarbonate dialysis (BD), 2–4 mmol/L of acetic acid are added to dialysate to maintain
salts in their soluble form. After giving up the hydrogen ion, the acetate anion diffuses into …

1) We performed detailed measurements of blood from both the arterial and venous limbs of
the hemodialysis circuit and of dialysate. Results of these analyses, for both bicarbonate …

Vascular calcification increases the mortality of maintenance hemodialysis patients, and the
acid-base environment in maintenance hemodialysis (MHD) patients may affect the …

The following system of equations is described in detail in a previously published article1,
and here is given only a condensed formulation. Supplementary Equations S1–S20 can be …