Pain is the primary reason that people seek medical care. At present, chronic unremitting
pain is the third greatest health problem after heart disease and cancer. Chronic pain is an …

There is a critical need for new analgesics acting through new mechanisms of action, which
could increase the efficacy respect to existing therapies and/or reduce their unwanted …

Injection of a dilute solution of formalin into a rat hindpaw produces a biphasic nociceptive
response consisting of an early phase during the first 5 min after formalin injection and a …

microRNAs (miRNAs) are small noncoding RNAs that have been linked to a number of
disease-related signal transduction pathways. Several studies indicate that they are also …

Considerable debate persists concerning peripheral vs. central mechanisms underlying the
second phase of the nociceptive response in the formalin test in the rat. To gain insight into …

Background Central neurotensin (NT) administration results in a naloxone-insensitive
antinociceptive response in animal models of acute and persistent pain. Both NTS1 and …

We have previously shown that the selective sigma‐1 receptor (σ1R) antagonist S1 RA (E‐
52862) inhibits neuropathic pain and activity‐induced spinal sensitization in various pre …

The present study has assessed the relationship between formalin-induced nociception and
formalin-induced inflammation by comparing the dose-related effects of anti-inflammatory …

Rats spinally transected at the second thoracic vertebra can learn to maintain their leg in a
flexed position if they receive legshock for extending the limb. These rats display an …

Glycine receptors (GlyRs) are the primary mediators of fast inhibitory transmission in
mammalian spinal cord, where they modulate sensory and motor signaling. Mutations in …