New approaches to stratify multiple myeloma patients based on prognosis and therapeutic
decision-making, or prediction, are needed since patients are currently managed in a similar …

Multiple myeloma (MM) is a genetically complex disease that evolves from pre-malignant
stages, such as monoclonal gammaopathy of undetermined significance and smouldering …

Multiple myeloma (MM) is characterized by the uncontrolled proliferation of plasma cells.
Despite recent treatment advances, it is still incurable as disease progression is not fully …

Based on the clinical features of myeloma and related malignancies of plasma cells, it has
been possible to generate a model system of myeloma progression from a normal plasma …

The outcomes for the majority of patients with myeloma have improved over recent decades,
driven by treatment advances. However, there is a subset of patients considered to have …

To date, the choice of therapy for an individual multiple myeloma patient has been based on
clinical factors such as age and comorbidities. The widespread evolution, validation, and …

To obtain a comprehensive genomic profile of presenting multiple myeloma cases we
performed high-resolution single nucleotide polymorphism mapping array analysis in 114 …

The multiple myeloma SET domain (MMSET) protein is overexpressed in multiple myeloma
(MM) patients with the translocation t (4; 14). Although studies have shown the involvement …

Background: Multiple myeloma is the second most common hematologic malignancy, which
to date remains incurable despite advances in treatment strategies including the use of …

Multiple myeloma (MM) is a plasma cell malignancy defined by complex genetics and
extensive patient heterogeneity. Despite a growing arsenal of approved therapies, MM …