[HTML][HTML] A systematic review of computational approaches to understand cancer biology for informed drug repurposing
Cancer is the second leading cause of death globally, trailing only heart disease. In the
United States alone, 1.9 million new cancer cases and 609,360 deaths were recorded for …
United States alone, 1.9 million new cancer cases and 609,360 deaths were recorded for …
[HTML][HTML] Reactive azo compounds as a potential chemotherapy drugs in the treatment of malignant glioblastoma (GBM): Experimental and theoretical studies
This research work focuses on the synthesis, spectroscopic characterization, DFT studies,
and in silico molecular docking of two azo compounds;(E)-6-((4, 6-dichloro-1, 3, 5-triazin-2 …
and in silico molecular docking of two azo compounds;(E)-6-((4, 6-dichloro-1, 3, 5-triazin-2 …
[HTML][HTML] NcRNAs: Multi‑angle participation in the regulation of glioma chemotherapy resistance
Z Zeng, Y Chen, X Geng, Y Zhang… - International …, 2022 - spandidos-publications.com
As the most common primary tumour of the central nervous system, gliomas have a high
recurrence rate after surgical resection and are resistant to chemotherapy, particularly high …
recurrence rate after surgical resection and are resistant to chemotherapy, particularly high …
Targeted nano-delivery of chemotherapy via intranasal route suppresses in vivo glioblastoma growth and prolongs survival in the intracranial mouse model
Nanotechnology-based drug delivery platforms have shown great potential in overcoming
the limitations of conventional therapy for glioblastoma (GBM). However, permeation across …
the limitations of conventional therapy for glioblastoma (GBM). However, permeation across …
Current opportunities for targeting dysregulated neurodevelopmental signaling pathways in glioblastoma
D Drakulic, M Schwirtlich, I Petrovic, M Mojsin… - Cells, 2022 - mdpi.com
Glioblastoma (GBM) is the most common and highly lethal type of brain tumor, with poor
survival despite advances in understanding its complexity. After current standard therapeutic …
survival despite advances in understanding its complexity. After current standard therapeutic …
Multiple therapeutic approaches of glioblastoma multiforme: from terminal to therapy
Glioblastoma multiforme (GBM) is an aggressive brain cancer showing poor prognosis.
Currently, treatment methods of GBM are limited with adverse outcomes and low survival …
Currently, treatment methods of GBM are limited with adverse outcomes and low survival …
Local delivery of doxorubicin prodrug via lipid nanocapsule–based hydrogel for the treatment of glioblastoma
M Wang, R Bergès, A Malfanti, V Préat… - Drug delivery and …, 2023 - Springer
Glioblastoma (GBM) recurrences appear in most cases around the resection cavity borders
and arise from residual GBM cells that cannot be removed by surgery. Here, we propose a …
and arise from residual GBM cells that cannot be removed by surgery. Here, we propose a …
Drug repurposing, a fast-track approach to develop effective treatments for glioblastoma
I Ntafoulis, SLW Koolen, S Leenstra, MLM Lamfers - Cancers, 2022 - mdpi.com
Simple Summary Introducing novel and effective treatments against glioblastoma (GBM)
remains an arduous journey as reflected in the negative outcome of most clinical trials. The …
remains an arduous journey as reflected in the negative outcome of most clinical trials. The …
High expression of PCOLCE gene indicate poor prognosis in patients and are associated with immune infiltration in glioma
Q Guo, X Gao, J Li, Y Liu, J Liu, H Yang, M Cui… - Scientific Reports, 2023 - nature.com
The procollagen C-protease enhancer (PCOLCE) has been identified to influence tumor
growth and metastasis in multiple cancers. However, the relationship between PCOLCE …
growth and metastasis in multiple cancers. However, the relationship between PCOLCE …
[HTML][HTML] Repurposing gemcitabine for glioblastoma treatment: the role of drug-conjugates and nanoparticles as drug delivery systems
MJ Ramalho, É Serra, JA Loureiro… - Journal of Drug Delivery …, 2024 - Elsevier
Gemcitabine (GEM) repurposing for glioblastoma (GBM) therapy has been investigated as a
fast-track approach to circumvent the drug resistance mediated by the O 6-alkylguanine …
fast-track approach to circumvent the drug resistance mediated by the O 6-alkylguanine …