[HTML][HTML] A systematic review of computational approaches to understand cancer biology for informed drug repurposing

F Ahmed, A Samantasinghar, AM Soomro, S Kim… - Journal of Biomedical …, 2023 - Elsevier
Cancer is the second leading cause of death globally, trailing only heart disease. In the
United States alone, 1.9 million new cancer cases and 609,360 deaths were recorded for …

[HTML][HTML] Reactive azo compounds as a potential chemotherapy drugs in the treatment of malignant glioblastoma (GBM): Experimental and theoretical studies

AD Udoikono, H Louis, EA Eno, EC Agwamba… - … of Photochemistry and …, 2022 - Elsevier
This research work focuses on the synthesis, spectroscopic characterization, DFT studies,
and in silico molecular docking of two azo compounds;(E)-6-((4, 6-dichloro-1, 3, 5-triazin-2 …

[HTML][HTML] NcRNAs: Multi‑angle participation in the regulation of glioma chemotherapy resistance

Z Zeng, Y Chen, X Geng, Y Zhang… - International …, 2022 - spandidos-publications.com
As the most common primary tumour of the central nervous system, gliomas have a high
recurrence rate after surgical resection and are resistant to chemotherapy, particularly high …

Targeted nano-delivery of chemotherapy via intranasal route suppresses in vivo glioblastoma growth and prolongs survival in the intracranial mouse model

P Sandbhor, J Goda, B Mohanty, P Gera… - Drug Delivery and …, 2023 - Springer
Nanotechnology-based drug delivery platforms have shown great potential in overcoming
the limitations of conventional therapy for glioblastoma (GBM). However, permeation across …

Current opportunities for targeting dysregulated neurodevelopmental signaling pathways in glioblastoma

D Drakulic, M Schwirtlich, I Petrovic, M Mojsin… - Cells, 2022 - mdpi.com
Glioblastoma (GBM) is the most common and highly lethal type of brain tumor, with poor
survival despite advances in understanding its complexity. After current standard therapeutic …

Multiple therapeutic approaches of glioblastoma multiforme: from terminal to therapy

S Kumari, R Gupta, RK Ambasta, P Kumar - Biochimica et Biophysica Acta …, 2023 - Elsevier
Glioblastoma multiforme (GBM) is an aggressive brain cancer showing poor prognosis.
Currently, treatment methods of GBM are limited with adverse outcomes and low survival …

Local delivery of doxorubicin prodrug via lipid nanocapsule–based hydrogel for the treatment of glioblastoma

M Wang, R Bergès, A Malfanti, V Préat… - Drug delivery and …, 2023 - Springer
Glioblastoma (GBM) recurrences appear in most cases around the resection cavity borders
and arise from residual GBM cells that cannot be removed by surgery. Here, we propose a …

Drug repurposing, a fast-track approach to develop effective treatments for glioblastoma

I Ntafoulis, SLW Koolen, S Leenstra, MLM Lamfers - Cancers, 2022 - mdpi.com
Simple Summary Introducing novel and effective treatments against glioblastoma (GBM)
remains an arduous journey as reflected in the negative outcome of most clinical trials. The …

High expression of PCOLCE gene indicate poor prognosis in patients and are associated with immune infiltration in glioma

Q Guo, X Gao, J Li, Y Liu, J Liu, H Yang, M Cui… - Scientific Reports, 2023 - nature.com
The procollagen C-protease enhancer (PCOLCE) has been identified to influence tumor
growth and metastasis in multiple cancers. However, the relationship between PCOLCE …

[HTML][HTML] Repurposing gemcitabine for glioblastoma treatment: the role of drug-conjugates and nanoparticles as drug delivery systems

MJ Ramalho, É Serra, JA Loureiro… - Journal of Drug Delivery …, 2024 - Elsevier
Gemcitabine (GEM) repurposing for glioblastoma (GBM) therapy has been investigated as a
fast-track approach to circumvent the drug resistance mediated by the O 6-alkylguanine …