SARS-CoV-2 infection is benign in most individuals but, in around 10% of cases, it triggers
hypoxaemic COVID-19 pneumonia, which leads to critical illness in around 3% of cases …

Many viruses, including SARS-CoV-2, can induce cellular senescence and exacerbate the
senescence-associated secretory phenotype, leading to detrimental hyperinflammatory …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection fatality rate (IFR)
doubles with every 5 y of age from childhood onward. Circulating autoantibodies …

Post-acute sequelae of COVID-19 (PASC) is emerging as global problem with unknown
molecular drivers. Using a digital epidemiology approach, we recruited 8,077 individuals to …

Recessive or dominant inborn errors of type I interferon (IFN) immunity can underlie critical
COVID-19 pneumonia in unvaccinated adults. The risk of COVID-19 pneumonia in …

Various lung insults can result in replacement of resident alveolar macrophages (AM) by
bone marrow monocyte–derived (BMo)–AM. However, the dynamics of this process and its …

Immune responses are governed by signals from the tissue microenvironment, and in
addition to biochemical signals, mechanical cues and forces arising from the tissue, its …

COVID's Omicron variant has sparked a slew of concerns across the globe. This review aims
to provide a brief overview of what we know about the Omicron variant right now. The new …

With the advent of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)
pandemic, several vaccines have been developed to mitigate its spread and prevent …

The outbreak of COVID-19 has become a global crisis, and brought severe disruptions to
societies and economies. Until now, effective therapeutics against COVID-19 are in high …