Hospital trajectories and early predictors of clinical outcomes differ between SARS-CoV-2 and influenza pneumonia

PG Lyons, SV Bhavani, A Mody, A Bewley, K Dittman… - …, 2022 - thelancet.com
Background A comparison of pneumonias due to SARS-CoV-2 and influenza, in terms of
clinical course and predictors of outcomes, might inform prognosis and resource …

Factors influencing influenza, pneumococcal and shingles vaccine uptake and refusal in older adults: a population-based cross-sectional study in England

P San Tan, M Patone, AK Clift, H Dambha-Miller… - BMJ open, 2023 - bmjopen.bmj.com
Objectives Uptake of influenza, pneumococcal and shingles vaccines in older adults vary
across regions and socioeconomic backgrounds. In this study, we study the coverage and …

Patho-physiology of aging and immune-senescence: possible correlates with comorbidity and mortality in middle-aged and old COVID-19 patients

S Farheen, S Agrawal, S Zubair, A Agrawal… - Frontiers in …, 2021 - frontiersin.org
During the last 2 years, the entire world has been severely devastated by the severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic (COVID-19) as it resulted in …

Tuberculosis and COVID-19 in the elderly: factors driving a higher burden of disease

A Allué-Guardia, JB Torrelles, A Sigal - Frontiers in Immunology, 2023 - frontiersin.org
Mycobacterium tuberculosis (M. tb) and SARS-CoV-2 are both infections that can lead to
severe disease in the lower lung. However, these two infections are caused by very different …

[HTML][HTML] Impact of Age and Variant Time Period on Clinical Presentation and Outcomes of Hospitalized Coronavirus Disease 2019 Patients

PK Srivastava, AM Klomhaus, DM Tehrani… - … : Innovations, Quality & …, 2023 - Elsevier
Objective To evaluate the impact of age and COVID-19 variant time period on morbidity and
mortality among those hospitalized with COVID-19. Patients and Methods Patients from the …

Incorporation of SARS-CoV-2 spike NTD to RBD protein vaccine improves immunity against viral variants

I Montgomerie, TW Bird, OR Palmer, NC Mason… - Iscience, 2023 - cell.com
Emerging SARS-CoV-2 variants pose a threat to human health worldwide. SARS-CoV-2
receptor binding domain (RBD)-based vaccines are suitable candidates for booster …

Analysis of the effect of cytomegalovirus infection in clinical outcomes and prolonged duration of SARS-CoV-2 shedding in intensive care unit patients with COVID-19 …

HC Shen, JY Feng, CY Sun, JR Huang… - Therapeutic …, 2023 - journals.sagepub.com
Background: Coronavirus disease 2019 (COVID-19) is a global outbreak disease caused by
the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection …

The use of alpha 1 thymosin as an immunomodulator of the response against SARS-Cov2

MS Espinar-Buitrago, L Tarancon-Diez… - Immunity & …, 2023 - Springer
Background Since the beginning of SARS-CoV2 pandemic, the mortality rate among elderly
patients (60–90 years) has been around 50%, so age has been a determining factor of a …

Challenges in the Vaccination of the Elderly and Strategies for Improvement

G Soegiarto, D Purnomosari - Pathophysiology, 2023 - mdpi.com
In recent years, the elderly has become a rapidly growing proportion of the world's
population as life expectancy is extending. Immunosenescence and inflammaging …

Interferons—Implications in the Immune Response to Respiratory Viruses

HC Bergeron, MR Hansen, RA Tripp - Microorganisms, 2023 - mdpi.com
Interferons (IFN) are an assemblage of signaling proteins made and released by various
host cells in response to stimuli, including viruses. Respiratory syncytial virus (RSV) …