Phosphatidylinositol 3′-kinase (PI3K) and Akt are signaling kinases involved in cell
survival and proliferation. Recent evidence suggests that PI3K/Akt activates the sterol …

The genus Gracilaria is an important marine bio-resource since some members are a source
of about 80% of the global production of agar. Moreover, species of Gracilaria are used in …

Eukaryotic life appears to have flourished surprisingly late in the history of our planet. This
view is based on the low diversity of diagnostic eukaryotic fossils in marine sediments of mid …

Sterols, essential lipids of most eukaryotic cells, ensure important structural and signaling
functions. The selection pressure that has led to different dominant sterols in the three …

Highlights What are the main findings? Hypothesis: Redox, bioenergetic and temperature
regulation is critical in maintaining cellular circadian rhythms; wakefulness is mainly …

The first eukaryote genome revealed three yeast cytochromes P450 (CYPs), hence the
subsequent realization that some microbial fungal genomes encode these proteins in 1 per …

Intracellular colonization and persistent infection by the kinetoplastid protozoan parasite,
Trypanosoma cruzi, underlie the pathogenesis of human Chagas disease. To obtain global …

The availability of complete genomes from a wide sampling of eukaryotic diversity has
allowed the application of phylogenomics approaches to study the origin and evolution of …

Squalene monooxygenase (SM) is a vital sterol synthesis enzyme across eukaryotic life. In
yeast, it is a therapeutic target for treating certain fungal infections, and in mammals it is a …

It is well-known that aqueous dispersions of phospholipids spontaneously assemble into
bilayer structures. These structures have numerous applications across chemistry and …