Asthma phenotyping and endotyping are constantly evolving. Currently, several biologic
agents have been developed towards a personalized approach to asthma management …

Eosinophils are innate immune cells typically associated with allergic and parasitic
diseases. However, in recent years, eosinophils have also been ascribed a role in keeping …

Neutrophils are cells of the innate immune system that are extremely abundant in vivo and
respond quickly to infection, injury, and inflammation. Their constant circulation throughout …

Background Eosinophilic asthma is a common subtype of severe asthma with high morbidity
and mortality. The cytokine IL-5 has been shown to be a key driver of the development and …

While type 2 immunity has traditionally been associated with the control of parasitic
infections and allergic reactions, increasing evidence suggests that type 2 immunity exerts …

Sex-based differences in bronchial asthma can already be observed in childhood, at which
time allergic atopic asthma is more frequently found in boys than in girls. In adulthood …

Antibodies are a type of protein produced by active B cells in response to antigen
stimulation. A series of monoclonal antibodies and neutralizing antibodies have been …

Background: Mepolizumab has been approved as a treatment option for severe eosinophilic
asthma (SEA) patients in our country. We aimed to evaluate the clinical and functional …

Background: Asthma is a prolonged inflammatory disorder of the airways, that affects an
estimated 300 million people worldwide. Asthma is triggered by numerous endogenous and …

Introduction Severe asthma is a heterogenous disease characterized by multiple
phenotypes. Targeted biologic therapies have revolutionarily changed the management of …