Polycystic ovary syndrome (PCOS) is a complex and heterogeneous endocrine disease
characterized by clinical or laboratorial hyperandrogenism, oligo-anovulation and metabolic …

Aging is a chronic yet natural physiological decline of the body. Throughout life, humans are
continuously exposed to a variety of exogenous and endogenous stresses, which engender …

Sirtuins are Class III protein deacetylases with seven conserved isoforms. In general,
Sirtuins are highly activated under cellular stress conditions in which NAD+ levels are …

Premature ovarian insufficiency (POI) is clinically irreversible in women aged over 40 years.
Although numerous studies have demonstrated satisfactory outcomes of mesenchymal stem …

Spinal cord injury (SCI) is one of the most incapacitating neurological disorders. It involves
complex pathological processes that include a primary injury and a secondary injury phase …

Sirtuins are an evolutionarily conserved family of regulatory proteins that function in an
NAD+-dependent manner. The mammalian family of sirtuins is composed of seven histone …

Oocyte quality is the limiting factor in female fertility. It is well known that maternal nutrition
plays a role in reproductive function, and manipulating nutrition to improve fertility in …

Aims Sirtuins have been implicated in the aging process, however, the functions of SIRT2 in
post-maturation aging of oocytes are not fully understood. The purpose of the present …

Chronic caloric restriction (CR) without malnutrition is known to affect different cellular
processes such as stem cell function, cell senescence, inflammation, and metabolism …

Commercial poultry production is associated with various types of stress leading to decrease
of productive and reproductive performance and compromised health of growing chickens …