The role of genetic and epigenetic factors in tumor initiation and progression is well
documented. Histone deacetylases (HDACs), histone methyl transferases (HMTs), and DNA …

Histone acetylation and deacetylation are important epigenetic mechanisms that regulate
gene expression and transcription. Histone deacetylase 6 (HDAC6) is a unique member of …

Purpose Entinostat is an oral isoform selective histone deacetylase inhibitor that targets
resistance to hormonal therapies in estrogen receptor–positive (ER+) breast cancer. This …

The liver executes versatile functions and is the chief organ for metabolism of
toxicants/xenobiotics. Hepatocellular carcinoma (HCC) is the most common primary liver …

Histone deacetylase inhibitors (HDACis) have now emerged as a powerful new class of
small-molecule therapeutics acting through the regulation of the acetylation states of histone …

Valproic acid is a widely-used first-generation antiepileptic drug, prescribed predominantly
in epilepsy and psychiatric disorders. VPA has good efficacy and pharmacoeconomic …

In recent years it has become widely recognized that histone modification plays a pivotal
role in controlling gene expression and is involved in a wide spectrum of disease regulation …

Perineural invasion is a common feature of pancreatic ductal adenocarcinoma (PDAC).
Here, we investigated the effect of perineural invasion on the microenvironment and how …

Lysine deacetylases inhibitors (KDACIs) are used in basic research, and many are being
investigated in clinical trials for treatment of cancer and other diseases. However, their …

Summary BAP1 (BRCA1-Associated Protein 1) was initially identified as a protein that binds
to BRCA1. BAP1 is a tumour suppressor that is believed to mediate its effects through …