[HTML][HTML] The glucagon-like peptide-1 (GLP-1) analogue semaglutide reduces alcohol drinking and modulates central GABA neurotransmission
Growing evidence indicates that the glucagon-like peptide-1 (GLP-1) system is involved in
the neurobiology of addictive behaviors, and GLP-1 analogues may be used for the …
the neurobiology of addictive behaviors, and GLP-1 analogues may be used for the …
Chemogenetic inhibition of central amygdala CRF-expressing neurons decreases alcohol intake but not trauma-related behaviors in a rat model of post-traumatic …
Post-traumatic stress disorder (PTSD) and alcohol use disorder (AUD) are often comorbid.
Few treatments exist to reduce comorbid PTSD/AUD. Elucidating the mechanisms …
Few treatments exist to reduce comorbid PTSD/AUD. Elucidating the mechanisms …
Orexin-mediated Motivated Arousal and Reward Seeking.
TE Bjorness, RW Greene - Peptides, 2024 - Elsevier
The neuromodulator orexin has been identified as a key factor for motivated arousal
including recent evidence that sleep deprivation-induced enhancement of reward behavior …
including recent evidence that sleep deprivation-induced enhancement of reward behavior …
LY2444296, a κ-opioid receptor antagonist, selectively reduces alcohol drinking in male and female Wistar rats with a history of alcohol dependence
FJ Flores-Ramirez, JM Illenberger, G Pascasio… - Scientific Reports, 2024 - nature.com
Alcohol use disorder (AUD) remains a major public health concern. The dynorphin (DYN)/κ-
opioid receptor (KOP) system is involved in actions of alcohol, particularly its withdrawal …
opioid receptor (KOP) system is involved in actions of alcohol, particularly its withdrawal …
Pivotal role of orexin signaling in the posterior paraventricular nucleus of the thalamus during the stress-induced reinstatement of oxycodone-seeking behavior
JM Illenberger, FJ Flores-Ramirez… - Journal of …, 2024 - journals.sagepub.com
Background: The orexin (OX) system has received increasing interest as a potential target
for treating substance use disorder. OX transmission in the posterior paraventricular nucleus …
for treating substance use disorder. OX transmission in the posterior paraventricular nucleus …
[HTML][HTML] Withdrawal from chronic alcohol impairs the serotonin-mediated modulation of GABAergic transmission in the infralimbic cortex in male rats
The infralimbic cortex (IL) is part of the medial prefrontal cortex (mPFC), exerting top-down
control over structures that are critically involved in the development of alcohol use disorder …
control over structures that are critically involved in the development of alcohol use disorder …
Chronic ethanol exposure produces long-lasting, subregion-specific physiological adaptations in RMTg-projecting mPFC neurons
KR Przybysz, JE Shillinglaw, SR Wheeler, EJ Glover - bioRxiv, 2024 - biorxiv.org
Chronic ethanol exposure produces neuroadaptations in the medial prefrontal cortex
(mPFC) which facilitate the maladaptive behaviors interfering with recovery from alcohol use …
(mPFC) which facilitate the maladaptive behaviors interfering with recovery from alcohol use …
A Systematic Review and Meta-analysis on the Transcriptomic Signatures in Alcohol Use Disorder
MM Friske, EC Torrico, MJW Haas, AM Borruto… - bioRxiv, 2022 - biorxiv.org
Alcohol use disorder (AUD) is a complex mental health condition. Currently available clinical
treatments exhibit limited efficacy and new druggable targets are required. One promising …
treatments exhibit limited efficacy and new druggable targets are required. One promising …